ID   TPGS2_RAT               Reviewed;         296 AA.
AC   Q6AXS8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Tubulin polyglutamylase complex subunit 2;
DE            Short=PGs2;
GN   Name=Tpgs2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Subunit of the tubulin polyglutamylase complex (TPGC). The
CC       complex mediates cilia and flagella polyglutamylation which is
CC       essential for their biogenesis and motility.
CC       {ECO:0000250|UniProtKB:Q68CL5}.
CC   -!- SUBUNIT: Part of the neuronal tubulin polyglutamylase complex which
CC       contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with CSTPP1
CC       and LRRC49. {ECO:0000250|UniProtKB:Q68CL5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q68CL5}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriolar satellite
CC       {ECO:0000250|UniProtKB:Q68CL5}. Note=Associated with microtubules.
CC       {ECO:0000250|UniProtKB:Q68CL5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH79332.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC079332; AAH79332.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001014169.2; NM_001014147.1.
DR   AlphaFoldDB; Q6AXS8; -.
DR   STRING; 10116.ENSRNOP00000020148; -.
DR   PaxDb; Q6AXS8; -.
DR   PRIDE; Q6AXS8; -.
DR   DNASU; 361301; -.
DR   Ensembl; ENSRNOT00000093690; ENSRNOP00000084578; ENSRNOG00000054118.
DR   GeneID; 361301; -.
DR   KEGG; rno:361301; -.
DR   UCSC; RGD:1310571; rat.
DR   CTD; 25941; -.
DR   RGD; 1310571; Tpgs2.
DR   eggNOG; ENOG502R21Z; Eukaryota.
DR   GeneTree; ENSGT00390000018344; -.
DR   InParanoid; Q6AXS8; -.
DR   OrthoDB; 1286883at2759; -.
DR   PhylomeDB; Q6AXS8; -.
DR   PRO; PR:Q6AXS8; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0018095; P:protein polyglutamylation; IEA:InterPro.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   InterPro; IPR039231; TPGS2.
DR   PANTHER; PTHR31854; PTHR31854; 1.
DR   SMART; SM00860; SMI1_KNR4; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..296
FT                   /note="Tubulin polyglutamylase complex subunit 2"
FT                   /id="PRO_0000079306"
FT   REGION          257..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  33163 MW;  C7F56E1D5661B578 CRC64;
     MEETPPPMQA GSKPHLEKLT LGVTRILESS PGVTEVSIIE KLPAERHMIS SWEQKNNCVM
     PEDVRNFYLM TNGFHMTWSV KLDDHIIPLG SMVINGISKL TQLIQSSVYS LPNAPTLADL
     EDDSQEGNED HQLEKPHFDC RSAIFELDSC GGNGKVCLVY KNGKPGLAHD TEIWFLDRAL
     YWHFLTDTFT AYYRLLITHL GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTSLLTEEPD
     TFVNKLDPSK VFKSKNKILI PKKKGPVQPV SGQKGPGPLA PPTSKPSAGC GNPVRK