BTUC_ECO57
ID BTUC_ECO57 Reviewed; 326 AA.
AC Q8X4L7;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Vitamin B12 import system permease protein BtuC;
GN Name=btuC; OrderedLocusNames=Z2740, ECs2418;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC vitamin B12 import. Involved in the translocation of the substrate
CC across the membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG56698.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB35841.1; -; Genomic_DNA.
DR PIR; B90931; B90931.
DR PIR; F85779; F85779.
DR RefSeq; NP_310445.1; NC_002695.1.
DR RefSeq; WP_000956513.1; NZ_SEKU01000008.1.
DR AlphaFoldDB; Q8X4L7; -.
DR SMR; Q8X4L7; -.
DR STRING; 155864.EDL933_2670; -.
DR EnsemblBacteria; AAG56698; AAG56698; Z2740.
DR EnsemblBacteria; BAB35841; BAB35841; ECs_2418.
DR GeneID; 912333; -.
DR KEGG; ece:Z2740; -.
DR KEGG; ecs:ECs_2418; -.
DR PATRIC; fig|386585.9.peg.2532; -.
DR eggNOG; COG4139; Bacteria.
DR HOGENOM; CLU_013016_0_3_6; -.
DR OMA; AMVYWSF; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3470.10; -; 1.
DR HAMAP; MF_01004; BtuC; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR023691; ABC_transptr_BtuC.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..326
FT /note="Vitamin B12 import system permease protein BtuC"
FT /id="PRO_0000059970"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 11..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 36..56
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 57..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 82..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 93..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 108..113
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 114..138
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 139..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 142..166
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 167..190
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 191..206
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 207..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 229..249
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 250..257
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 258..267
FT /note="Helical; Name=8"
FT /evidence="ECO:0000250"
FT TOPO_DOM 268..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 275..296
FT /note="Helical; Name=9"
FT /evidence="ECO:0000250"
FT TOPO_DOM 297..304
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 305..324
FT /note="Helical; Name=10"
FT /evidence="ECO:0000250"
FT TOPO_DOM 325..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 326 AA; 34939 MW; BE09441DA21566C9 CRC64;
MLTLARQQQR QNIRWLLCLS VLMLLALLLS LCAGEQWISP GDWFSPRGEL FVWQIRLPRT
LAVLLVGAAL AISGAVMQAL FENPLAEPGL LGVSNGAGVG LIAAVLLGQG QLPNWALGLC
AIAGALIITL ILLRFARRHL STSRLLLAGV ALGIICSALM TWAIYFSTSV DLRQLMYWMM
GGFGGVDWRQ SWLMLALIPM LLWICCQSRP MNMLALGEIS ARQLGLPLWF WRNVLVAATG
WMVGVSVALA GAIGFIGLVI PHILRLCGLT DHRALLPGCA LAGASALLLA DIVARLALAA
AELPIGVVTA TLGAPVFIWL LLKAGR
