ACA1_YEAST
ID ACA1_YEAST Reviewed; 489 AA.
AC P39970; D3DLU6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=ATF/CREB activator 1;
GN Name=ACA1; OrderedLocusNames=YER045C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=10825197; DOI=10.1128/mcb.20.12.4340-4349.2000;
RA Garcia-Gimeno M.A., Struhl K.;
RT "Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are
RT important for carbon source utilization but not the response to stress.";
RL Mol. Cell. Biol. 20:4340-4349(2000).
RN [4]
RP FUNCTION.
RX PubMed=12051917; DOI=10.1016/s0022-2836(02)00322-4;
RA Spode I., Maiwald D., Hollenberg C.P., Suckow M.;
RT "ATF/CREB sites present in sub-telomeric regions of Saccharomyces
RT cerevisiae chromosomes are part of promoters and act as UAS/URS of highly
RT conserved COS genes.";
RL J. Mol. Biol. 319:407-420(2002).
RN [5]
RP FUNCTION.
RX PubMed=14966276; DOI=10.1128/mcb.24.5.1956-1967.2004;
RA Oki M., Valenzuela L., Chiba T., Ito T., Kamakaka R.T.;
RT "Barrier proteins remodel and modify chromatin to restrict silenced
RT domains.";
RL Mol. Cell. Biol. 24:1956-1967(2004).
RN [6]
RP FUNCTION.
RX PubMed=16464826; DOI=10.1093/nar/gkj493;
RA Titz B., Thomas S., Rajagopala S.V., Chiba T., Ito T., Uetz P.;
RT "Transcriptional activators in yeast.";
RL Nucleic Acids Res. 34:955-967(2006).
RN [7]
RP INDUCTION.
RX PubMed=17252314; DOI=10.1007/s10482-006-9135-1;
RA Jimenez-Marti E., Aranda A., Mendes-Ferreira A., Mendes-Faia A.,
RA del Olmo M.L.;
RT "The nature of the nitrogen source added to nitrogen depleted vinifications
RT conducted by a Saccharomyces cerevisiae strain in synthetic must affects
RT gene expression and the levels of several volatile compounds.";
RL Antonie Van Leeuwenhoek 92:61-75(2007).
CC -!- FUNCTION: Transcriptional activator of promoters containing ATF/CREB
CC sites. Can independently stimulate transcription through ATF/CREB
CC sites. Important for a variety of biological functions including growth
CC on non-optimal carbon sources. Regulates the expression of COS8. Has
CC efficient silencing blocking activities. {ECO:0000269|PubMed:10825197,
CC ECO:0000269|PubMed:12051917, ECO:0000269|PubMed:14966276,
CC ECO:0000269|PubMed:16464826}.
CC -!- INTERACTION:
CC P39970; P40535: CST6; NbExp=2; IntAct=EBI-22524, EBI-2052;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- INDUCTION: By nitrogen limitation. {ECO:0000269|PubMed:17252314}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
CC -!- CAUTION: This ORF was incorrectly assigned as MEI4. {ECO:0000305}.
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DR EMBL; U18796; AAB64580.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07700.1; -; Genomic_DNA.
DR PIR; S50548; S50548.
DR RefSeq; NP_010964.3; NM_001178936.3.
DR AlphaFoldDB; P39970; -.
DR SMR; P39970; -.
DR BioGRID; 36782; 76.
DR DIP; DIP-1535N; -.
DR IntAct; P39970; 6.
DR MINT; P39970; -.
DR STRING; 4932.YER045C; -.
DR iPTMnet; P39970; -.
DR PaxDb; P39970; -.
DR PRIDE; P39970; -.
DR EnsemblFungi; YER045C_mRNA; YER045C; YER045C.
DR GeneID; 856769; -.
DR KEGG; sce:YER045C; -.
DR SGD; S000000847; ACA1.
DR VEuPathDB; FungiDB:YER045C; -.
DR eggNOG; KOG1414; Eukaryota.
DR GeneTree; ENSGT00940000176485; -.
DR HOGENOM; CLU_638108_0_0_1; -.
DR InParanoid; P39970; -.
DR OMA; NQAYINM; -.
DR BioCyc; YEAST:G3O-30224-MON; -.
DR Reactome; R-SCE-3214847; HATs acetylate histones.
DR Reactome; R-SCE-450341; Activation of the AP-1 family of transcription factors.
DR PRO; PR:P39970; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P39970; protein.
DR GO; GO:0005634; C:nucleus; IC:SGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR029810; Aca1/Aca2.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR19304:SF40; PTHR19304:SF40; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..489
FT /note="ATF/CREB activator 1"
FT /id="PRO_0000076537"
FT DOMAIN 384..447
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 386..406
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 412..419
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 489 AA; 54592 MW; 2850D6C3DDF5C29D CRC64;
MDYKHNFATS PDSFLDGRQN PLLYTDFLSS NKELIYKQPS GPGLVDSAYN FHHQNSLHDR
SVQENLGPMF QPFGVDISHL PITNPPIFQS SLPAFDQPVY KRRISISNGQ ISQLGEDLET
VENLYNCQPP ILSSKAQQNP NPQQVANPSA AIYPSFSSNE LQNVPQPHEQ ATVIPEAAPQ
TGSKNIYAAM TPYDSNIKLN IPAVAATCDI PSATPSIPSG DSTMNQAYIN MQLRLQAQMQ
TKAWKNAQLN VHPCTPASNS SVSSSSSCQN INDHNIENQS VHSSISHGVN HHTVNNSCQN
AELNISSSLP YESKCPDVNL THANSKPQYK DATSALKNNI NSEKDVHTAP FSSMHTTATF
QIKQEARPQK IENNTAGLKD GAKAWKRARL LERNRIAASK CRQRKKMSQL QLQREFDQIS
KENTMMKKKI ENYEKLVQKM KKISRLHMQE CTINGGNNSY QSLQNKDSDV NGFLKMIEEM
IRSSSLYDE
