TPIS_AEDTO
ID TPIS_AEDTO Reviewed; 206 AA.
AC P92119;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Triosephosphate isomerase;
DE Short=TIM;
DE EC=5.3.1.1;
DE AltName: Full=Triose-phosphate isomerase;
DE Flags: Fragment;
GN Name=Tpi;
OS Aedes togoi (Mosquito) (Ochlerotatus togoi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Finlaya.
OX NCBI_TaxID=55967;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9294007; DOI=10.1016/s0167-4781(97)00065-1;
RA Tyshenko M.G., Walker V.K.;
RT "Towards a reconciliation of the introns early or late views:
RT triosephosphate isomerase genes from insects.";
RL Biochim. Biophys. Acta 1353:131-136(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate;
CC Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776;
CC EC=5.3.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10127};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|PROSITE-ProRule:PRU10127}.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate from glycerone phosphate: step 1/1. {ECO:0000255|PROSITE-
CC ProRule:PRU10127}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|PROSITE-ProRule:PRU10127}.
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
CC {ECO:0000255|PROSITE-ProRule:PRU10127}.
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DR EMBL; U82708; AAB48449.1; -; Genomic_DNA.
DR AlphaFoldDB; P92119; -.
DR SMR; P92119; -.
DR UniPathway; UPA00109; UER00189.
DR UniPathway; UPA00138; -.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00311; TIM; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00147_B; TIM_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035990; TIM_sf.
DR InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; SSF51351; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS00171; TIM_1; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis; Glycolysis; Isomerase.
FT CHAIN <1..>206
FT /note="Triosephosphate isomerase"
FT /id="PRO_0000090124"
FT ACT_SITE 76
FT /note="Electrophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10127"
FT ACT_SITE 146
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10127"
FT NON_TER 1
FT NON_TER 206
SQ SEQUENCE 206 AA; 21925 MW; AD89BBA000FF8B69 CRC64;
SIAELCKVLT TGPLNADTEV VVGCPAPYLT LARSQLPDSV GVAAQNCYKV AKGAFTGEIS
PAMLKDLNIG WVILGHSERR AIFGESDELI ADKVAHALAE GLKVIACIGE TLQEREAGQT
EAVCFRQTKA IADKVKDWSN VVVAYEPVWA IGTGKTATPE QAQEVHVALR KWFTDNVSAD
VSASIRIQYG GSVTAANCRE LAAKPD