ID   BTUC_ECOBW              Reviewed;         326 AA.
AC   C4ZYH3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN   Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004}; OrderedLocusNames=BWG_1525;
OS   Escherichia coli (strain K12 / MC4100 / BW2952).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=595496;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MC4100 / BW2952;
RX   PubMed=19376874; DOI=10.1128/jb.00118-09;
RA   Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R.,
RA   Wang L.;
RT   "Genomic sequencing reveals regulatory mutations and recombinational events
RT   in the widely used MC4100 lineage of Escherichia coli K-12.";
RL   J. Bacteriol. 191:4025-4029(2009).
CC   -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC       vitamin B12 import. Involved in the translocation of the substrate
CC       across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01004}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
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DR   EMBL; CP001396; ACR65779.1; -; Genomic_DNA.
DR   RefSeq; WP_000956528.1; NC_012759.1.
DR   AlphaFoldDB; C4ZYH3; -.
DR   SMR; C4ZYH3; -.
DR   KEGG; ebw:BWG_1525; -.
DR   HOGENOM; CLU_013016_0_3_6; -.
DR   OMA; AMVYWSF; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   HAMAP; MF_01004; BtuC; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR023691; ABC_transptr_BtuC.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..326
FT                   /note="Vitamin B12 import system permease protein BtuC"
FT                   /id="PRO_1000213143"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ   SEQUENCE   326 AA;  34949 MW;  C65882B1C47BFE69 CRC64;
     MLTLARQQQR QNIRWLLCLS VLMLLALLLS LCAGEQWISP GDWFTPRGEL FVWQIRLPRT
     LAVLLVGAAL AISGAVMQAL FENPLAEPGL LGVSNGAGVG LIAAVLLGQG QLPNWALGLC
     AIAGALIITL ILLRFARRHL STSRLLLAGV ALGIICSALM TWAIYFSTSV DLRQLMYWMM
     GGFGGVDWRQ SWLMLALIPV LLWICCQSRP MNMLALGEIS ARQLGLPLWF WRNVLVAATG
     WMVGVSVALA GAIGFIGLVI PHILRLCGLT DHRVLLPGCA LAGASALLLA DIVARLALAA
     AELPIGVVTA TLGAPVFIWL LLKAGR