ID   BTUC_KLEP7              Reviewed;         331 AA.
AC   A6TAH6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN   Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN   OrderedLocusNames=KPN78578_21360; ORFNames=KPN_02169;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC       vitamin B12 import. Involved in the translocation of the substrate
CC       across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01004}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000647; ABR77597.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6TAH6; -.
DR   SMR; A6TAH6; -.
DR   STRING; 272620.KPN_02169; -.
DR   EnsemblBacteria; ABR77597; ABR77597; KPN_02169.
DR   KEGG; kpn:KPN_02169; -.
DR   HOGENOM; CLU_013016_0_3_6; -.
DR   OMA; AMVYWSF; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   HAMAP; MF_01004; BtuC; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR023691; ABC_transptr_BtuC.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="Vitamin B12 import system permease protein BtuC"
FT                   /id="PRO_0000318865"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ   SEQUENCE   331 AA;  35579 MW;  A3A58AAA170A95E6 CRC64;
     MESMLTLAHL QQRRSRRWLF GLTLLLLVTL LISLCAGEQW IPPGEWLSAK GQLFIWQIRL
     PRTLAVLLVG AALALSGAIM QALFENPLAE PGLLGISNGA GVGLIAAVLL GKGVLPGWAL
     GLCAIFGALL ITFILLRFAR RHLSTSRLLL AGVALGIICS ALMTWAVYFS TSFDLRQLMY
     WMMGGFGGVD WQQLWLMIAL LPVLCWVCLQ SQPLNLLALG EVSARQLGLP LWLWRKLLVV
     ATGWMVGVSV ALAGAIGFIG LVIPHILRLC GLSDHRVLLP ACMMAGASAL LGADIIARLA
     LSAAELPIGV VTATLGAPVF IWLLLRSRGR G