ID   BTUC_SERP5              Reviewed;         335 AA.
AC   A8GDR2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN   Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004}; OrderedLocusNames=Spro_2151;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC       vitamin B12 import. Involved in the translocation of the substrate
CC       across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01004}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000826; ABV41252.1; -; Genomic_DNA.
DR   RefSeq; WP_012144883.1; NC_009832.1.
DR   AlphaFoldDB; A8GDR2; -.
DR   SMR; A8GDR2; -.
DR   STRING; 399741.Spro_2151; -.
DR   EnsemblBacteria; ABV41252; ABV41252; Spro_2151.
DR   KEGG; spe:Spro_2151; -.
DR   eggNOG; COG4139; Bacteria.
DR   HOGENOM; CLU_013016_0_3_6; -.
DR   OMA; AMVYWSF; -.
DR   OrthoDB; 1283908at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   HAMAP; MF_01004; BtuC; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR023691; ABC_transptr_BtuC.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..335
FT                   /note="Vitamin B12 import system permease protein BtuC"
FT                   /id="PRO_1000062776"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ   SEQUENCE   335 AA;  35957 MW;  8DA51EC857C48380 CRC64;
     MPASQTFTLL LHKQRHRDKR HLLLLTLGVA VAFVFSLSAG DVWLWPSQWS GEAAQLFVWQ
     LRLPRALAVM LVGASLAVAG AVMQSLFENP LAEPGLLGVA NGAGVALVLT VLLGNGLLPV
     AFMSLSAIAG ALVMTFLLLS FARRKRLTNA RLLLVGVALG IVCSAVMTWA VYFSSSLDLR
     QLMYWMMGGF GGVDWRQKWL VLALLPVLLW LCCQGKALNF MALGEVQARQ LGLSLHLWRN
     LLVLAIGWLV GVSVALAGVI GFVGLVIPHM LRLSGLTNQR YLLPGCALAG AGVLLAADVV
     ARITLLSAEL PIGVVTATLG APLFIWLLTR VKSLR