BTUC_SHIFL
ID BTUC_SHIFL Reviewed; 326 AA.
AC Q7C1M5; Q83RG0;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN OrderedLocusNames=SF1520, S1637;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC vitamin B12 import. Involved in the translocation of the substrate
CC across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01004}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
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DR EMBL; AE005674; AAN43110.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP17000.1; -; Genomic_DNA.
DR RefSeq; NP_707403.1; NC_004337.2.
DR RefSeq; WP_000956532.1; NZ_WPGW01000051.1.
DR AlphaFoldDB; Q7C1M5; -.
DR SMR; Q7C1M5; -.
DR STRING; 198214.SF1520; -.
DR EnsemblBacteria; AAN43110; AAN43110; SF1520.
DR EnsemblBacteria; AAP17000; AAP17000; S1637.
DR GeneID; 1024714; -.
DR GeneID; 58390280; -.
DR KEGG; sfl:SF1520; -.
DR KEGG; sft:NCTC1_01639; -.
DR KEGG; sfx:S1637; -.
DR PATRIC; fig|198214.7.peg.1795; -.
DR HOGENOM; CLU_013016_0_3_6; -.
DR OMA; AMVYWSF; -.
DR OrthoDB; 1283908at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3470.10; -; 1.
DR HAMAP; MF_01004; BtuC; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR023691; ABC_transptr_BtuC.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..326
FT /note="Vitamin B12 import system permease protein BtuC"
FT /id="PRO_0000059978"
FT TRANSMEM 13..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 90..107
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 111..133
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 188..205
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ SEQUENCE 326 AA; 34967 MW; 264D831B75D0E4D8 CRC64;
MLTLARQQQR QNIRWLLCLS VLMLLALLLS LCAGEQWISP GDWFTPRGEL FVWQIRLPRT
LAVLLVGAAL AISGAVMQAL FENPLAEPGL LGVSNGAGVG LIAAVLLGQG QLPNWALGLC
AIAGALIITL ILLRFARRHL STSRLLLAGV ALGIICSALM TWAIYFSTSV DLRQLMYWMM
GGFGGVDWRQ SWLMLALIPV LLWICCQSRP MNMLALGEIS ARQLGLPMWF WRNVLVAATG
WMVGVSVALA GAIGFIGLVI PHILRLCGLT DHRVLLPGCA LAGASALLLA DIVARLALAA
AELPIGVVTA TLGAPVFIWL LLKAGR
