BTUC_VIBCH
ID BTUC_VIBCH Reviewed; 331 AA.
AC Q9KSL2;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004}; OrderedLocusNames=VC_1244;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC vitamin B12 import. Involved in the translocation of the substrate
CC across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01004}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF94403.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE003852; AAF94403.1; ALT_INIT; Genomic_DNA.
DR PIR; G82224; G82224.
DR RefSeq; NP_230889.1; NC_002505.1.
DR RefSeq; WP_000345511.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KSL2; -.
DR SMR; Q9KSL2; -.
DR STRING; 243277.VC_1244; -.
DR DNASU; 2614681; -.
DR EnsemblBacteria; AAF94403; AAF94403; VC_1244.
DR GeneID; 57739913; -.
DR KEGG; vch:VC_1244; -.
DR PATRIC; fig|243277.26.peg.1184; -.
DR eggNOG; COG4139; Bacteria.
DR HOGENOM; CLU_013016_0_3_6; -.
DR OMA; AMVYWSF; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015889; P:cobalamin transport; IBA:GO_Central.
DR Gene3D; 1.10.3470.10; -; 1.
DR HAMAP; MF_01004; BtuC; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR023691; ABC_transptr_BtuC.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..331
FT /note="Vitamin B12 import system permease protein BtuC"
FT /id="PRO_0000059979"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 117..136
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 148..170
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 190..209
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 306..325
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ SEQUENCE 331 AA; 35497 MW; F00191E154F68F3A CRC64;
MDFHRLLQHK QQRWQRSSYL LIGLFLSVCV LYLLVGELWL SPFSAWSSLE QQLVWELRLP
RLLAAAVIGA SLAVAGATLQ VLLGNVLAEP GVVGVSGGAS VAMVILLLFF PSLNSPVAFM
AAAVLGALLF TLLLVVMARK LRLTTARLLL VGVALGILSG AVVTWAFYFS DDLGLRQLMY
WLMGSVAGVS WYQHLLSLVA VPVVIWLVLQ GGVLDKLMLG EGHAKQLGID IHRVRWRLIL
AIALLVGASV ALGGVIGFVG LVVPHLLRLT LGSENRLLLP LSALCGALLL VSADLIARLA
LGSGELPLGV VTTTLGAPIF IWMLVRNHDS C