ID   BTUC_VIBPA              Reviewed;         331 AA.
AC   Q87Q39;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN   Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004}; OrderedLocusNames=VP1311;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC       vitamin B12 import. Involved in the translocation of the substrate
CC       across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01004}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC59574.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000031; BAC59574.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_797690.1; NC_004603.1.
DR   RefSeq; WP_005454796.1; NC_004603.1.
DR   AlphaFoldDB; Q87Q39; -.
DR   SMR; Q87Q39; -.
DR   STRING; 223926.28806299; -.
DR   EnsemblBacteria; BAC59574; BAC59574; BAC59574.
DR   GeneID; 1188816; -.
DR   KEGG; vpa:VP1311; -.
DR   PATRIC; fig|223926.6.peg.1253; -.
DR   eggNOG; COG4139; Bacteria.
DR   HOGENOM; CLU_013016_0_3_6; -.
DR   OMA; AMVYWSF; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015889; P:cobalamin transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   HAMAP; MF_01004; BtuC; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR023691; ABC_transptr_BtuC.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="Vitamin B12 import system permease protein BtuC"
FT                   /id="PRO_0000059980"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        91..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        118..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        147..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        189..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        240..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        277..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT   TRANSMEM        306..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ   SEQUENCE   331 AA;  35749 MW;  13D4A4DBCD5A5E1A CRC64;
     MDFQQLILNK ERRWQRNLVI MSVVLVLLST IHLMVGEVFL SPFQSLSVFE QKLLLDLRLP
     RLVAAAMIGA ALAVSGATLQ VLLGNVLAEP GVLGISGGAS LAMVLVMFAL PVLPTPMIFM
     LAAIAGSMLF TLILVGIARA MHLTTARLLL VGVALGILSS AIVTWAFYFS DDLSLRQLMY
     WLMGSIGGAS WYQHTVTLVM LPVLVWLCCQ GKPLDKLMLG EIHATQLGVD VHQMRWKLIL
     AISVLVGCSV ALGGIISFVG LVVPHLLRLA FGTENRYLLP LSAIFGAALL VFADIGARLL
     LDSAELPLGV MTTSIGAPIF IWMLVKSHDA R