ID   TPIS_SCHJA              Reviewed;         252 AA.
AC   Q27775; Q27773;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=TPI;
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Chinese, and Philippines;
RX   PubMed=8946393; DOI=10.1016/0166-6851(96)02748-x;
RA   Hooker C.W., Brindley P.J.;
RT   "Cloning and characterisation of strain-specific transcripts encoding
RT   triosephosphate isomerase, a candidate vaccine antigen from Schistosoma
RT   japonicum.";
RL   Mol. Biochem. Parasitol. 82:265-269(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate;
CC         Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776;
CC         EC=5.3.1.1;
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; U50847; AAC47393.1; -; mRNA.
DR   EMBL; U43343; AAC47855.1; -; mRNA.
DR   AlphaFoldDB; Q27775; -.
DR   SMR; Q27775; -.
DR   PRIDE; Q27775; -.
DR   UniPathway; UPA00109; UER00189.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00311; TIM; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00147_B; TIM_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR035990; TIM_sf.
DR   InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR   PANTHER; PTHR21139; PTHR21139; 1.
DR   Pfam; PF00121; TIM; 1.
DR   SUPFAM; SSF51351; SSF51351; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   2: Evidence at transcript level;
KW   Gluconeogenesis; Glycolysis; Isomerase.
FT   CHAIN           1..252
FT                   /note="Triosephosphate isomerase"
FT                   /id="PRO_0000090139"
FT   ACT_SITE        96
FT                   /note="Electrophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        169
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         12
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         14
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   VARIANT         3
FT                   /note="G -> S (in strain: Chinese)"
FT   VARIANT         120
FT                   /note="E -> G (in strain: Chinese)"
SQ   SEQUENCE   252 AA;  27662 MW;  2A329800E83CDF39 CRC64;
     MSGSRKFFVG GNWKMNGSRA DNKVLIHSLS EAHFCGDTEI LIAAPFVYLN EVRQSLAKEI
     HVAAQNCYKV PKGAFTGEIS PSMIKDVGCD WVILGHSERR SIFNESDELV AEKVQHALAE
     GLSVVACIGE TLSERESGKT EEVCVRQLNA IANKIKSIDE WKRVVVAYEP VWAIGTGKVA
     SPGQAQEVHN FLRKWFKTNT PSGVDQQIRI IYGGSVTAAN CKELAQQHDV DGFLVGGASL
     KPEFIDICKA RQ