BTUC_YERPE
ID BTUC_YERPE Reviewed; 335 AA.
AC Q8ZDX4; Q0WEA0;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Vitamin B12 import system permease protein BtuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN Name=btuC {ECO:0000255|HAMAP-Rule:MF_01004};
GN OrderedLocusNames=YPO2425, y1914, YP_2212;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Part of the ABC transporter complex BtuCDF involved in
CC vitamin B12 import. Involved in the translocation of the substrate
CC across the membrane. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01004}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01004}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000255|HAMAP-Rule:MF_01004}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM85481.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS62418.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL21052.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM85481.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS62418.1; ALT_INIT; Genomic_DNA.
DR PIR; AI0295; AI0295.
DR RefSeq; WP_002220283.1; NZ_WUCM01000025.1.
DR RefSeq; YP_002347388.1; NC_003143.1.
DR AlphaFoldDB; Q8ZDX4; -.
DR SMR; Q8ZDX4; -.
DR IntAct; Q8ZDX4; 6.
DR STRING; 214092.YPO2425; -.
DR PaxDb; Q8ZDX4; -.
DR DNASU; 1146861; -.
DR EnsemblBacteria; AAM85481; AAM85481; y1914.
DR EnsemblBacteria; AAS62418; AAS62418; YP_2212.
DR GeneID; 66841233; -.
DR KEGG; ype:YPO2425; -.
DR KEGG; ypk:y1914; -.
DR KEGG; ypm:YP_2212; -.
DR PATRIC; fig|1028802.3.peg.951; -.
DR eggNOG; COG4139; Bacteria.
DR HOGENOM; CLU_013016_0_3_6; -.
DR OMA; AMVYWSF; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015889; P:cobalamin transport; IBA:GO_Central.
DR Gene3D; 1.10.3470.10; -; 1.
DR HAMAP; MF_01004; BtuC; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR023691; ABC_transptr_BtuC.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..335
FT /note="Vitamin B12 import system permease protein BtuC"
FT /id="PRO_0000059983"
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01004"
SQ SEQUENCE 335 AA; 36332 MW; 839381BADF5E5A74 CRC64;
MQTSQLFTAL QQRQRQRDYR YLTGLVVMLL FALLISLCAG DVWIWPEHWF SESGKLFVWQ
LRLPRSMAVI MVGASLAVSG AVMQALFENP LAEPGLLGVA NGAGVALVTA VLLGHGLLPI
WVLSTCAIIG ALLMTSILLS FTRRRLLTNA QLLLVGVALG IICSAMMTWA VYFSTSLDLR
QLMYWMMGGF SGVDWRQQSL VLALLPTVIW LCCQGRVLNF MSLGEQQARQ LGVSLHLWRN
LLVLAIGLLV GISVALAGVI SFIGLVIPHI LRLTGLTDQR RLLAGCAFAG GGVLLLADVV
ARTVLSSAEL PIGVVTATLG SPLFIWLLIR VKGVK
