ID   BTUDA_HALSA             Reviewed;         398 AA.
AC   Q9HQ18;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Cobalamin import ATP-binding protein BtuD;
DE            EC=7.6.2.8;
DE   AltName: Full=Vitamin B12-transporting ATPase;
GN   Name=btuD; Synonyms=hemV2; OrderedLocusNames=VNG_1371G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   FUNCTION IN CORRINOID UTILIZATION.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=16109931; DOI=10.1128/jb.187.17.5901-5909.2005;
RA   Woodson J.D., Reynolds A.A., Escalante-Semerena J.C.;
RT   "ABC transporter for corrinoids in Halobacterium sp. strain NRC-1.";
RL   J. Bacteriol. 187:5901-5909(2005).
CC   -!- FUNCTION: Required for corrinoid utilization. Probably part of the ABC
CC       transporter complex BtuCDF involved in cobalamin (vitamin B12) import.
CC       Probably responsible for energy coupling to the transport system.
CC       {ECO:0000269|PubMed:16109931}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an R-cob(III)alamin(out) + ATP + H2O = ADP + an R-
CC         cob(III)alamin(in) + H(+) + phosphate; Xref=Rhea:RHEA:17873,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:140785, ChEBI:CHEBI:456216;
CC         EC=7.6.2.8;
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG19699.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE004437; AAG19699.1; ALT_INIT; Genomic_DNA.
DR   PIR; G84291; G84291.
DR   RefSeq; WP_010902995.1; NC_002607.1.
DR   AlphaFoldDB; Q9HQ18; -.
DR   SMR; Q9HQ18; -.
DR   STRING; 64091.VNG_1371G; -.
DR   TCDB; 3.A.1.14.9; the atp-binding cassette (abc) superfamily.
DR   PaxDb; Q9HQ18; -.
DR   EnsemblBacteria; AAG19699; AAG19699; VNG_1371G.
DR   GeneID; 5953596; -.
DR   KEGG; hal:VNG_1371G; -.
DR   PATRIC; fig|64091.14.peg.1047; -.
DR   HOGENOM; CLU_000604_0_0_2; -.
DR   InParanoid; Q9HQ18; -.
DR   OrthoDB; 68573at2157; -.
DR   PhylomeDB; Q9HQ18; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..398
FT                   /note="Cobalamin import ATP-binding protein BtuD"
FT                   /id="PRO_0000408969"
FT   DOMAIN          3..237
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         35..42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   398 AA;  40466 MW;  524C614B8196F48A CRC64;
     MTLDVTGLDV ELAGTRILDD VHASIRDGHL VGVVGPNGAG KSTLLRAMNG LITPTAGTVL
     VAGDDVHALS SAAASRRIAT VPQDASVSFE FTVRQVVEMG RHPHTTRFGT DTDTAVVDRA
     MARTGVAQFA ARDVTSLSGG ERQRVLLARA LAQAAPVLLL DEPTASLDVN HQIRTLEVVR
     DLADSEDRAV VAAIHDLDLA ARYCDELVVV ADGRVHDAGA PRSVLTPDTI RAAFDARVAV
     GTDPATGAVT VTPLPDRTSA AADTSVHVVG GGDSATPVVR RLVSAGASVS VGPVVEGDTD
     HETARRVGCP CTSVAPFTRL EDTTAASATR ADIAAADVIA VPVAAAARPG VRGLLTGAVP
     TLAVGDAAGA PEWADRLVAC DAVVSAVGAL ADTPSDGV