TPIS_ZYGBA
ID TPIS_ZYGBA Reviewed; 248 AA.
AC Q9C401;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Triosephosphate isomerase;
DE Short=TIM;
DE EC=5.3.1.1;
DE AltName: Full=Triose-phosphate isomerase;
GN Name=TPI1;
OS Zygosaccharomyces bailii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=4954;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ISA 1307;
RX PubMed=11427959; DOI=10.1002/yea.727;
RA Merico A., Rodrigues F., Corte-Real M., Porro D., Maria Ranzi B.,
RA Compagno C.;
RT "Isolation and sequence analysis of the gene encoding triose phosphate
RT isomerase from Zygosaccharomyces bailii.";
RL Yeast 18:775-780(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate;
CC Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776;
CC EC=5.3.1.1;
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate from glycerone phosphate: step 1/1.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
CC {ECO:0000305}.
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DR EMBL; AF325852; AAG50278.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9C401; -.
DR SMR; Q9C401; -.
DR UniPathway; UPA00109; UER00189.
DR UniPathway; UPA00138; -.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00311; TIM; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00147_B; TIM_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035990; TIM_sf.
DR InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; SSF51351; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS00171; TIM_1; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis; Glycolysis; Isomerase.
FT CHAIN 1..248
FT /note="Triosephosphate isomerase"
FT /id="PRO_0000090170"
FT ACT_SITE 95
FT /note="Electrophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 10
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 12
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 248 AA; 27027 MW; B92446E294185F89 CRC64;
MARTFFVGGN FKLNGTKSSI KEIVERLNNA KLDPKVEVVL CPPAPYLDYT VSLVKKSQVS
VGAQNAYLKA SGAFTGENSV DQIKDVGAKW VILGHSERRQ YFREDDQLIA EKTAFALSQG
VGVILCIGET LDQKKAGTTL QVVERQLQAV IDKVKDWSNV VIAYEPVWAI GTGLAATPED
AQEIHHSIRE FLAKKLGEKT AQETRILYGG SANGKNAVTF KDKPDVDGFL VGGASLKPEF
VDIINSRS