ID   TPK_RANTE               Reviewed;          10 AA.
AC   P56923;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Temporin-1Tk {ECO:0000250|UniProtKB:P56917};
DE            Short=TK {ECO:0000250|UniProtKB:P56917};
DE   AltName: Full=Temporin-K {ECO:0000303|PubMed:9022710};
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-10, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skin secretion;
RX   PubMed=9022710; DOI=10.1111/j.1432-1033.1996.0788r.x;
RA   Simmaco M., Mignogna G., Canofeni S., Miele R., Mangoni M.L., Barra D.;
RT   "Temporins, antimicrobial peptides from the European red frog Rana
RT   temporaria.";
RL   Eur. J. Biochem. 242:788-792(1996).
CC   -!- FUNCTION: Amphipathic alpha-helical antimicrobial peptide with potent
CC       activity against Gram-positive bacteria, weak activity against Gram-
CC       negative bacteria, and moderate activity against fungi.
CC       {ECO:0000250|UniProtKB:P79874}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9022710}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:9022710}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Temporin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00100";
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Fungicide; Immunity; Innate immunity; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Temporin-1Tk"
FT                   /evidence="ECO:0000269|PubMed:9022710"
FT                   /id="PRO_0000043584"
FT   MOD_RES         10
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:9022710"
SQ   SEQUENCE   10 AA;  1123 MW;  390549B337272457 CRC64;
     LLPNLLKSLL