TPL2A_DANRE
ID TPL2A_DANRE Reviewed; 186 AA.
AC Q1ECV8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Tumor necrosis factor, alpha-induced protein 8-like protein 2 A;
DE Short=TIPE2 A;
DE Short=TNF alpha-induced protein 8-like protein 2 A;
DE Short=TNFAIP8-like protein 2 A;
GN Name=tnfaip8l2a; ORFNames=si:dkey-24a7.9, zgc:136816;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC by maintaining immune homeostasis. Negative regulator of Toll-like
CC receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC the immune system and maintains immune homeostasis. Inhibits jun/ap1
CC and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC similarity). {ECO:0000250}.
CC -!- DOMAIN: The central region was initially thought to constitute a DED
CC (death effector) domain. However, 3D-structure data reveal a previously
CC uncharacterized fold that is different from the predicted fold of a DED
CC (death effector) domain. It consists of a large, hydrophobic central
CC cavity that is poised for cofactor binding (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC {ECO:0000305}.
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DR EMBL; CU571385; CAX13646.1; -; Genomic_DNA.
DR EMBL; BC117652; AAI17653.1; -; mRNA.
DR RefSeq; NP_001038766.1; NM_001045301.1.
DR AlphaFoldDB; Q1ECV8; -.
DR SMR; Q1ECV8; -.
DR STRING; 7955.ENSDARP00000093501; -.
DR PaxDb; Q1ECV8; -.
DR Ensembl; ENSDART00000102725; ENSDARP00000093501; ENSDARG00000075592.
DR GeneID; 723996; -.
DR KEGG; dre:723996; -.
DR CTD; 723996; -.
DR ZFIN; ZDB-GENE-060616-38; tnfaip8l2a.
DR eggNOG; ENOG502QST4; Eukaryota.
DR GeneTree; ENSGT00390000003488; -.
DR HOGENOM; CLU_085918_1_0_1; -.
DR InParanoid; Q1ECV8; -.
DR OMA; REFTRSC; -.
DR OrthoDB; 1284744at2759; -.
DR PhylomeDB; Q1ECV8; -.
DR TreeFam; TF323415; -.
DR PRO; PR:Q1ECV8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000075592; Expressed in granulocyte and 15 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.20.1440.160; -; 1.
DR InterPro; IPR008477; TNFAIP8-like.
DR InterPro; IPR038355; TNFAIP8_sf.
DR PANTHER; PTHR12757; PTHR12757; 1.
DR Pfam; PF05527; DUF758; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Reference proteome.
FT CHAIN 1..186
FT /note="Tumor necrosis factor, alpha-induced protein 8-like
FT protein 2 A"
FT /id="PRO_0000369397"
SQ SEQUENCE 186 AA; 21355 MW; A45E633F36085D14 CRC64;
MEAFSSKDMA MQAQKKILSR MASKSVAQMF IDDNSSEVLD ELYRVSKEHS GNRAEAQKVV
KNMIKIAVKV GVLFRHEKFS AEELSIAQEF RKKLHHGAMT AISFQEVEFT FDKSVMINLL
SDCRDLLLKL VEKHLTPKSL DRIRHVFNHY SNPELLTHLY DPQGNLWSNL SKICSGLNRM
IEEGKL
