ID   TPL2B_DANRE             Reviewed;         186 AA.
AC   Q7T364;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Tumor necrosis factor, alpha-induced protein 8-like protein 2 B;
DE            Short=TIPE2 B;
DE            Short=TNF alpha-induced protein 8-like protein 2 B;
DE            Short=TNFAIP8-like protein 2 B;
GN   Name=tnfaip8l2b; Synonyms=tnfaip8l, tnfaip8l2; ORFNames=zgc:64074;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of innate and adaptive immunity
CC       by maintaining immune homeostasis. Negative regulator of Toll-like
CC       receptor and T-cell receptor function. Prevents hyperresponsiveness of
CC       the immune system and maintains immune homeostasis. Inhibits jun/ap1
CC       and NF-kappa-B activation. Promotes Fas-induced apoptosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The central region was initially thought to constitute a DED
CC       (death effector) domain. However, 3D-structure data reveal a previously
CC       uncharacterized fold that is different from the predicted fold of a DED
CC       (death effector) domain. It consists of a large, hydrophobic central
CC       cavity that is poised for cofactor binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC053238; AAH53238.1; -; mRNA.
DR   RefSeq; NP_956668.1; NM_200374.1.
DR   AlphaFoldDB; Q7T364; -.
DR   SMR; Q7T364; -.
DR   STRING; 7955.ENSDARP00000067853; -.
DR   PaxDb; Q7T364; -.
DR   Ensembl; ENSDART00000067854; ENSDARP00000067853; ENSDARG00000046148.
DR   Ensembl; ENSDART00000150617; ENSDARP00000125388; ENSDARG00000046148.
DR   GeneID; 393345; -.
DR   KEGG; dre:393345; -.
DR   CTD; 393345; -.
DR   ZFIN; ZDB-GENE-040426-1359; tnfaip8l2b.
DR   eggNOG; ENOG502QST4; Eukaryota.
DR   GeneTree; ENSGT00390000003488; -.
DR   HOGENOM; CLU_085918_1_0_1; -.
DR   InParanoid; Q7T364; -.
DR   OMA; HDRISHV; -.
DR   OrthoDB; 1284744at2759; -.
DR   PhylomeDB; Q7T364; -.
DR   TreeFam; TF323415; -.
DR   Reactome; R-DRE-1483255; PI Metabolism.
DR   PRO; PR:Q7T364; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000046148; Expressed in zone of skin and 25 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.20.1440.160; -; 1.
DR   InterPro; IPR008477; TNFAIP8-like.
DR   InterPro; IPR038355; TNFAIP8_sf.
DR   PANTHER; PTHR12757; PTHR12757; 1.
DR   Pfam; PF05527; DUF758; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Tumor necrosis factor, alpha-induced protein 8-like
FT                   protein 2 B"
FT                   /id="PRO_0000285774"
SQ   SEQUENCE   186 AA;  21301 MW;  3B3E5DEFBC49C3C7 CRC64;
     METFSSKDMA LKAQKKILSK MATKSMVQMI IDDTSSEILD ELYRVSKEYT GNRSEAQKVV
     KDLIKVVVKI GVLFRHNRFN EEELKLAQNF QKKLRQGAMT AISFHEVDFT FDKTVMSDIL
     TESRDMLLKL VNTHLTTKSH GRINHVFNHY ADPELLTQLY NSSGPLKPHL NKICNGLNKL
     LENGTL