ID   TPL_PASMU               Reviewed;         458 AA.
AC   Q9CMK9;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Tyrosine phenol-lyase;
DE            EC=4.1.99.2;
DE   AltName: Full=Beta-tyrosinase;
GN   Name=tpl; OrderedLocusNames=PM0811;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-tyrosine = NH4(+) + phenol + pyruvate;
CC         Xref=Rhea:RHEA:21704, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15882, ChEBI:CHEBI:28938, ChEBI:CHEBI:58315; EC=4.1.99.2;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-eliminating lyase family.
CC       {ECO:0000305}.
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DR   EMBL; AE004439; AAK02895.1; -; Genomic_DNA.
DR   RefSeq; WP_005722479.1; NC_002663.1.
DR   AlphaFoldDB; Q9CMK9; -.
DR   SMR; Q9CMK9; -.
DR   STRING; 747.DR93_1650; -.
DR   EnsemblBacteria; AAK02895; AAK02895; PM0811.
DR   KEGG; pmu:PM0811; -.
DR   HOGENOM; CLU_047223_0_0_6; -.
DR   OMA; VYTYAHM; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0050371; F:tyrosine phenol-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006570; P:tyrosine metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   HAMAP; MF_00543; Tyr_phenol_lyase; 1.
DR   InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR   InterPro; IPR011166; Beta-eliminating_lyase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR018176; Tryptophanase_CS.
DR   InterPro; IPR013441; Tyr_phenol_ly.
DR   Pfam; PF01212; Beta_elim_lyase; 1.
DR   PIRSF; PIRSF001386; Trpase; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR02618; tyr_phenol_ly; 1.
DR   PROSITE; PS00853; BETA_ELIM_LYASE; 1.
PE   3: Inferred from homology;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..458
FT                   /note="Tyrosine phenol-lyase"
FT                   /id="PRO_0000195636"
FT   MOD_RES         258
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   458 AA;  51441 MW;  AF0A9FA08F0F84B1 CRC64;
     MRNYPAEPYK VKAVEPIAMT TREQREAYMK KAGYNTFLLN SEEVYIDLLT DSGTSAMSDK
     QWAGLMIGDE AYAGSRNFMH LQDVVREYYG FKYVVPTHQG RGAENLLSTI MIKPGDYVPG
     NMYFTTTRAH QERNGATFVD IIIDEAHDSQ IDLPFKGNVD VKKLQKLIDE VGADKIPYIC
     LAVTVNLAGG QPVSMANMRE VKALCSKHGI KVMFDATRCV ENAYFIKERE AEYKDATIKD
     ILKEMMSYAD GCTMSGKKDC LVNIGGFLCI NDDDLYQQAC ELVVLFEGMP SYGGLAGRDM
     EAMAIGITES VDFHYIQHRV AQCYYLADKL EAAGVPIVKP VGGHAVFLDA KKFLPHIPQE
     QFPAQMLAAQ IYIEGGVRSM ERGIVSAGRD KKTGANHTPK LELVRLTIPR RVYTYAHLDH
     VADTIIKLFK HRDDIKGLDM VYEPKLLRFF TARFEPKA