ID   TPL_TREPA               Reviewed;         233 AA.
AC   P45685;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Protein tpl;
GN   Name=tpl; OrderedLocusNames=TP_0046;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RA   Jones T.S., Vega R.B., Tryon V.V.;
RT   "Cloning of signal peptidase II-like activity from Treponema pallidum
RT   subspecies pallidum, the syphilis spirochete.";
RL   Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Supposed to have signal peptidase II-like activity.
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DR   EMBL; U11881; AAA20395.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65042.1; -; Genomic_DNA.
DR   PIR; H71371; H71371.
DR   RefSeq; WP_010881495.1; NC_021490.2.
DR   AlphaFoldDB; P45685; -.
DR   SMR; P45685; -.
DR   IntAct; P45685; 31.
DR   STRING; 243276.TPANIC_0046; -.
DR   PRIDE; P45685; -.
DR   EnsemblBacteria; AAC65042; AAC65042; TP_0046.
DR   GeneID; 57878587; -.
DR   KEGG; tpa:TP_0046; -.
DR   eggNOG; COG1774; Bacteria.
DR   HOGENOM; CLU_033149_2_5_12; -.
DR   OMA; CCHAVSD; -.
DR   OrthoDB; 1523756at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   InterPro; IPR007557; PSP1_C.
DR   Pfam; PF04468; PSP1; 1.
DR   PROSITE; PS51411; PSP1_C; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..233
FT                   /note="Protein tpl"
FT                   /id="PRO_0000072649"
FT   DOMAIN          85..170
FT                   /note="PSP1 C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00744"
SQ   SEQUENCE   233 AA;  26872 MW;  B672F2471B3E0DA1 CRC64;
     MIPKLSPNAD PCTACASTPA FPPQPMEEEG EFLYQLRLEY SREVLYARFH AALRVHTFVV
     VPTRYGNDIA RCVGRIRTPV QTDIASVVRV ASDQDLCTWH IHREKERAAE MIFRDRIEHY
     QLEMKCICCH YPLEEARVVF LYSAPARVDF RELVRDLGAT FGTRVELRQI NEREEARIVG
     GIDCCGRALC CCSVFSRLRP VSVKMVKEKN LLFRSTQMMG RCGRLRCCLT FEE