ID   TPM01_PERAM             Reviewed;         284 AA.
AC   P0DSM6; O97144; Q9UB83;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Tropomyosin Per a 7.0101 {ECO:0000305};
DE   AltName: Full=Allergen Per a 7 {ECO:0000303|PubMed:10201967};
DE   AltName: Allergen=Per a 7.0101 {ECO:0000305};
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=10201967;
RA   Asturias J.A., Gomez-Bayon N., Arilla M.C., Martinez A., Palacios R.,
RA   Sanchez-Gascon F., Martinez J.;
RT   "Molecular characterization of American cockroach tropomyosin (Periplaneta
RT   americana allergen 7), a cross-reactive allergen.";
RL   J. Immunol. 162:4342-4348(1999).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction. {ECO:0000250|UniProtKB:Q22866}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P40414}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity. {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 41% of
CC       29 household insect P.americana-allergic patients living in France.
CC       {ECO:0000269|PubMed:10201967}.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; Y14854; CAB38086.1; -; mRNA.
DR   AlphaFoldDB; P0DSM6; -.
DR   SMR; P0DSM6; -.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Muscle protein; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin Per a 7.0101"
FT                   /id="PRO_0000205689"
FT   COILED          22..266
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  32777 MW;  1B91486A94446CF1 CRC64;
     MDAIKKKMQA MKLEKDNAMD CALLCEQQAR DANLRAEKAE EEARSLQKKI QQIENDLDQT
     MEQLMQVNAK LDEKDKALQN AESEVAALNR RIQLLEEDLE RSEERLATAT AKLAEASQAV
     DESERARKIL ESKGLADEER MDALENQLKE ARFMAEEADK KYDEVARKLA MVEADLERAE
     ERAESGESKI VELEEELRVV GNNLKSLEVS EEKANLREEE YKQQIKTLTT RLKEAEARAE
     FAERSVQKLQ KEVDRLEDEL VHEKEKYKFI CDDLDMTFTE LAGY