ID   TPM02_PERAM             Reviewed;         284 AA.
AC   P0DSM7; O97144; Q9UB83;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Tropomyosin Per a 7.0102 {ECO:0000305};
DE   AltName: Full=Major allergen Per a 7 {ECO:0000303|PubMed:10452753};
DE   AltName: Allergen=Per a 7.0102 {ECO:0000305};
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND ALLERGEN.
RX   PubMed=10452753; DOI=10.1016/s0091-6749(99)70375-1;
RA   Santos A.B., Chapman M.D., Aalberse R.C., Vailes L.D., Ferriani V.P.,
RA   Oliver C., Rizzo M.C., Naspitz C.K., Arruda L.K.;
RT   "Cockroach allergens and asthma in Brazil: identification of tropomyosin as
RT   a major allergen with potential cross-reactivity with mite and shrimp
RT   allergens.";
RL   J. Allergy Clin. Immunol. 104:329-337(1999).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction. {ECO:0000250|UniProtKB:Q22866}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P40414}.
CC   -!- TISSUE SPECIFICITY: Expressed in striated skeletal muscle (at protein
CC       level). {ECO:0000269|PubMed:10452753}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity. {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 50% of
CC       53 cockroach-allergic patients living in Brazil.
CC       {ECO:0000269|PubMed:10452753}.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; AF106961; AAD19606.1; -; mRNA.
DR   AlphaFoldDB; P0DSM7; -.
DR   SMR; P0DSM7; -.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Muscle protein; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin Per a 7.0102"
FT                   /id="PRO_0000447186"
FT   COILED          1..266
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  32794 MW;  2EAB56416A4D163C CRC64;
     MDAIKKKMQA MKLEKDNAMD RALLCEQQAR DANLRAEKAE EEARSLQKKI QQIENDLDQT
     MEQLMQVNAK LDEKDKALQN AESEVAALNR RIQLLEEDLE RSEERLATAT AKLAEASQAA
     DESERARKIL ESKGLADEER MDALENQLKE ARFMAEEADK KYDEVARKLA MVEADLERAE
     ERAESGESKI VELEEELRVV GNNLKSLEVS EEKANLREEE YKQQIKTLTT RLKEAEARAE
     FAERSVQKLQ KEVDRLEDEL VHEKEKYKFI CDDLDMTFTE LIGI