ID   TPM03_PERAM             Reviewed;         284 AA.
AC   C5J049;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Tropomyosin Per a 7.0103 {ECO:0000305};
DE   AltName: Full=Tropomyosin Per a 7 {ECO:0000303|PubMed:19548625};
DE   AltName: Allergen=Per a 7.0103 {ECO:0000305};
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978 {ECO:0000312|EMBL:ACS14052.1};
RN   [1] {ECO:0000312|EMBL:ACS14052.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=19548625;
RA   Sookrung N., Indrawattana N., Tungtrongchitr A., Bunnag C.,
RA   Tantilipikorn P., Kwangsri S., Chaicumpa W.;
RT   "Allergenicity of native/recombinant tropomyosin, per a 7, of American
RT   cockroach (CR), Periplaneta americana, among CR allergic Thais.";
RL   Asian Pac. J. Allergy Immunol. 27:9-17(2009).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction. {ECO:0000250|UniProtKB:Q22866}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P40414}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity. {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Native and recombinant
CC       protein binds to IgE in 57% and 43%, respectively, of 14 Thai patients
CC       allergic to cockroach P.americana. {ECO:0000269|PubMed:19548625}.
CC   -!- SIMILARITY: Belongs to the tropomyosin family.
CC       {ECO:0000255|RuleBase:RU004515, ECO:0000305}.
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DR   EMBL; FJ976895; ACS14052.1; -; mRNA.
DR   AlphaFoldDB; C5J049; -.
DR   SMR; C5J049; -.
DR   Allergome; 542; Per a 7.
DR   Allergome; 7725; Per a 7.0103.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Muscle protein; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin Per a 7.0103"
FT                   /id="PRO_0000447187"
FT   COILED          1..266
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  32862 MW;  595C9D3937DFC306 CRC64;
     MDAIKKKMQA MKLEKDNAMD RALLCEQQAR DANLRAEKAE EEARSLQKKT QQIENDLDQT
     MEQLMQVNAK LDEKDKALQN AESEVAALNR RIQLLEEDLE RSEERLATAT AKLAEASQAD
     DESERARKIL ESKGLADEER MDALENQLKE ARFMAEEADK KYDEVARKLA MVEADLERAE
     ERAESGESKI VELEEELRVV GNNLKSLEVS EEKANLREEE YKQQIKTLTT RLKEAEARAE
     FAERSVQKLQ KEVDRLEDEL VHEKEKYKFI CDDLDMTFTE LVGY