TPM1_BOMMO
ID TPM1_BOMMO Reviewed; 284 AA.
AC Q1HPU0; P82200; Q1HPP6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Tropomyosin-1;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1] {ECO:0000312|EMBL:ABF51401.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Niu B.L., Meng Z.Q., Weng H.B., Shen W.F., He L.H., Zheng K.F., Ye S.T.,
RA Lin T.B., Chen J.E.;
RT "Blast silkworm EST database for functional genes.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 15-46.
RC STRAIN=Xinhang X Keming {ECO:0000269|PubMed:11280994};
RC TISSUE=Body wall {ECO:0000269|PubMed:11280994}, and
RC Fat body {ECO:0000269|PubMed:11280994};
RX PubMed=11280994;
RA Zhong B.-X.;
RT "Protein database for several tissues derived from five instar of
RT silkworm.";
RL Yi Chuan Xue Bao 28:217-224(2001).
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction. {ECO:0000305}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P15846}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|Ref.1};
CC IsoId=Q1HPU0-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|Ref.1}; Synonyms=5 {ECO:0000269|Ref.1};
CC IsoId=Q1HPU0-2; Sequence=VSP_052285;
CC -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC polypeptide chains. The sequence exhibits a prominent seven-residues
CC periodicity. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000255}.
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DR EMBL; DQ443312; ABF51401.1; -; mRNA.
DR EMBL; DQ443356; ABF51445.1; -; mRNA.
DR RefSeq; NP_001040445.1; NM_001046980.1. [Q1HPU0-1]
DR AlphaFoldDB; Q1HPU0; -.
DR SMR; Q1HPU0; -.
DR STRING; 7091.BGIBMGA001587-TA; -.
DR Allergome; 4112; Bomb m 7.
DR Allergome; 4114; Bomb m 7.0102.
DR PRIDE; Q1HPU0; -.
DR EnsemblMetazoa; BGIBMGA001587-RA; BGIBMGA001587-TA; BGIBMGA001587.
DR GeneID; 732984; -.
DR KEGG; bmor:732984; -.
DR eggNOG; KOG1003; Eukaryota.
DR HOGENOM; CLU_055027_0_2_1; -.
DR InParanoid; Q1HPU0; -.
DR OMA; DEASRMC; -.
DR OrthoDB; 1576041at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR InterPro; IPR000533; Tropomyosin.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Direct protein sequencing;
KW Reference proteome; Repeat.
FT CHAIN 1..284
FT /note="Tropomyosin-1"
FT /id="PRO_0000274257"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..276
FT /evidence="ECO:0000255"
FT COMPBIAS 109..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 258..284
FT /note="DELGINKDRYKSLADEMDSTFAELAGY -> GNTNVYKTETNLSF (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_052285"
SQ SEQUENCE 284 AA; 32508 MW; 5E8A79B0FD79DADD CRC64;
MDAIKKKMQA MKLEKDNAMD KADTCEQQAR DANLRAEKVN EEVRELQKKL AQVEEDLILN
KNKLEQANKD LEEKEKQLTA TEAEVAALNR KVQQIEEDLE KSEERSGTAQ QKLLEAQQSA
DENNRMCKVL ENRAQQDEER MDQLTNQLKE ARLLAEDADG KSDEVSRKLA FVEDELEVAE
DRVKSGDAKI SELEEELKVV GNSLKSLEVS EEKANQRVEE FKKQLKTLTG KLKEAEARAE
YAEKTVKKLQ KEVDRLEDEL GINKDRYKSL ADEMDSTFAE LAGY
