ID   TPM1_CIOIN              Reviewed;         284 AA.
AC   Q07068;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Tropomyosin, smooth muscle/fibroblast CTM1;
GN   Name=CTM1;
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Body wall muscle;
RX   PubMed=8454648; DOI=10.1016/s0021-9258(18)53314-7;
RA   Meedel T.H., Hastings K.E.M.;
RT   "Striated muscle-type tropomyosin in a chordate smooth muscle, ascidian
RT   body-wall muscle.";
RL   J. Biol. Chem. 268:6755-6764(1993).
CC   -!- FUNCTION: The function of tropomyosin in smooth muscle and non-muscle
CC       cells is not clear.
CC   -!- SUBUNIT: Homodimer.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in body wall muscle and
CC       heart, low in intestine, ovary and larval tail muscle.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; X64105; CAA45469.1; -; mRNA.
DR   PIR; A45488; A45488.
DR   RefSeq; NP_001027710.1; NM_001032538.1.
DR   AlphaFoldDB; Q07068; -.
DR   SMR; Q07068; -.
DR   STRING; 7719.XP_002119123.1; -.
DR   PRIDE; Q07068; -.
DR   GeneID; 100185771; -.
DR   eggNOG; KOG1003; Eukaryota.
DR   InParanoid; Q07068; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin, smooth muscle/fibroblast CTM1"
FT                   /id="PRO_0000205658"
FT   REGION          18..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
FT   VARIANT         191
FT                   /note="I -> N (may represent an allelic variant or a
FT                   cloning artifact)"
SQ   SEQUENCE   284 AA;  32230 MW;  860AC29C7130FD62 CRC64;
     MEAIKKKMTM LKLDKENAID RAEQAETDKK SAEDKATGLE EELQGLQKRL KATEDELDTS
     QEKLRTAIEN LENAEKKAAD AEQEVASLNR RITLVEEELD RAQERLTISL SKLEEAEKAA
     DESERGRKVI ENRSLKDEER LEVQEIQLTE AKNIAEDADR KYVEVARKLV MVEAELERGE
     ERAELAESKA IELEEELKIV ANNLKSLEAS AEKYAAKEGI FEEEIKTLSD KLKDSETRAE
     FAEKSVVKLE KNIDELEDSL YAEKCKIKAI SEDMDVTLQG IGDL