ID   TPM1_SCHMA              Reviewed;         284 AA.
AC   P42637;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tropomyosin-1;
DE   AltName: Full=Polypeptide 49;
DE   AltName: Full=Tropomyosin I;
DE            Short=SmTMI;
DE            Short=TMI;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2806461; DOI=10.1016/0014-4894(89)90087-8;
RA   Xu H., Miller S., van Kuelen H., Wawrzynski M.R., Rekosh D.M.,
RA   Loverde P.T.;
RT   "Schistosoma mansoni tropomyosin: cDNA characterization, sequence,
RT   expression, and gene product localization.";
RL   Exp. Parasitol. 69:373-392(1989).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at much higher levels in the adult worm
CC       stage as compared to the cercariae and the egg stages.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M27512; AAA03011.1; -; mRNA.
DR   PIR; A60607; A60607.
DR   RefSeq; XP_018650430.1; XM_018796193.1.
DR   AlphaFoldDB; P42637; -.
DR   SMR; P42637; -.
DR   STRING; 6183.Smp_044010.2; -.
DR   EnsemblMetazoa; Smp_340760.3; Smp_340760.3; Smp_340760.
DR   GeneID; 8350309; -.
DR   KEGG; smm:Smp_044010.1; -.
DR   WBParaSite; Smp_340760.3; Smp_340760.3; Smp_340760.
DR   CTD; 8350309; -.
DR   eggNOG; KOG1003; Eukaryota.
DR   HOGENOM; CLU_055027_0_2_1; -.
DR   OMA; TEKRATN; -.
DR   OrthoDB; 1576041at2759; -.
DR   PhylomeDB; P42637; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   ExpressionAtlas; P42637; baseline.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin-1"
FT                   /id="PRO_0000205656"
FT   REGION          111..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
SQ   SEQUENCE   284 AA;  32954 MW;  991630F1D8BBDE2B CRC64;
     MDGIKKKMIA MKLEKENAME RAVQYEELLK KKEEEREKRE SEIAELNNKM KQAQIDCDEA
     QETLQEQMNK LEETDKRATN AEAEVAAMTR RIRLLEEDLE VSSSRLTETL TKLEEASKTA
     EESERGRKDL EIRSIADDER LNQLEDQQKE AKYIAEDADR KYDEAARKLA IAEVDFERAE
     ARLEAAESKI VELEEELRVV GNNMKALEIS EQESAQREES YEETIRDLTE RLKAAEQRAT
     EAERQVSKLQ NEVDHLEDDL LAEKERYKAL SGELDQTFAE LTGY