ID   TPM2_BIOGL              Reviewed;         284 AA.
AC   P43689;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Tropomyosin-2;
DE   AltName: Full=Tropomyosin II;
DE            Short=BgTMII;
DE            Short=TMII;
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Brazilian;
RX   PubMed=7685709; DOI=10.1006/expr.1993.1044;
RA   Weston D.S., Kemp W.M.;
RT   "Schistosoma mansoni: comparison of cloned tropomyosin antigens shared
RT   between adult parasites and Biomphalaria glabrata.";
RL   Exp. Parasitol. 76:358-370(1993).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; M97554; AAA27816.1; -; mRNA.
DR   AlphaFoldDB; P43689; -.
DR   SMR; P43689; -.
DR   STRING; 6526.P43689; -.
DR   VEuPathDB; VectorBase:BGLB011792; -.
DR   Proteomes; UP000076420; Genome assembly.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin-2"
FT                   /id="PRO_0000205663"
FT   REGION          103..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   284 AA;  32683 MW;  2E6103712D9B4C33 CRC64;
     MDAIKKKMLA MKMEKENAID RAEQMEQKVR DVEETKNKLE EEFNNLQKKF SNLQNDFDTA
     NEGLTEAQTK LEASEKHVAE LESDTAGLNR RIQLLEEDLE RSEERLQSAT EKLEEASKAA
     DESERGRKVL ESRSLADDER LDGLEAQLKE AKYIAEDAER KYDEAARKLA ITEVDLERAE
     ARLEAAEAKI IELEEELKVV GNNMKSLEIS EQEASQREDS YEETIRDLTQ RLKDAENRAT
     EAERTVSKLQ KEVDRLEDEL LAEKERYKSI SDELDSTFAE LAGY