ID   TPM2_SCHMA              Reviewed;         284 AA.
AC   P42638;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Tropomyosin-2;
DE   AltName: Full=Tropomyosin II;
DE            Short=SmTMII;
DE            Short=TMII;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=LE;
RX   PubMed=7685709; DOI=10.1006/expr.1993.1044;
RA   Weston D.S., Kemp W.M.;
RT   "Schistosoma mansoni: comparison of cloned tropomyosin antigens shared
RT   between adult parasites and Biomphalaria glabrata.";
RL   Exp. Parasitol. 76:358-370(1993).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Associated with the protective tegument surrounding
CC       the sporocyst.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M97555; AAA29942.1; -; mRNA.
DR   RefSeq; XP_018653709.1; XM_018798795.1.
DR   AlphaFoldDB; P42638; -.
DR   SMR; P42638; -.
DR   STRING; 6183.Smp_031770.1; -.
DR   EnsemblMetazoa; Smp_031770.1; Smp_031770.1; Smp_031770.
DR   GeneID; 8350461; -.
DR   KEGG; smm:Smp_031770.1; -.
DR   WBParaSite; Smp_031770.1; Smp_031770.1; Smp_031770.
DR   CTD; 8350461; -.
DR   eggNOG; KOG1003; Eukaryota.
DR   HOGENOM; CLU_055027_0_2_1; -.
DR   PhylomeDB; P42638; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin-2"
FT                   /id="PRO_0000205657"
FT   REGION          56..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
SQ   SEQUENCE   284 AA;  32696 MW;  33C8F9BDE50428CF CRC64;
     MEHIKKKMLA MKLDKENAVD EADQLEAKLR EKELEMQTKD EEVAEVLKKI QQVDTDKETA
     QTQLAETNTK LEETDKRATE AEAEVASLQK RIRQLEDELE STETRLQEAT VKLEEASKAA
     DESDRGRKVL ENRTFADEER INQLEEQLKE STFMAEDADR KYDEAARKLA ITEVELERAE
     SRLEAAESKI TELEEELRIV GNNVKSLEIS EQEAAQREEA YEENIRDLTE RLKAAEDRAQ
     ESERLVNTLQ ADADRLEDEL VTEKEKYKAL SEELDSTFAE LTGN