ID   TPM_ACAVI               Reviewed;         284 AA.
AC   O01673;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Tropomyosin;
OS   Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX   NCBI_TaxID=6277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Muscle;
RA   Adam R., Hartmann S., von Nickisch-Rosenegk E., Lucius R.;
RT   "Molecular cloning and characterization of tropomyosin, a protective
RT   antigen of Acanthocheilonema viteae.";
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; AF000607; AAB53807.1; -; mRNA.
DR   AlphaFoldDB; O01673; -.
DR   SMR; O01673; -.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205644"
FT   REGION          113..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
SQ   SEQUENCE   284 AA;  33247 MW;  885714CB0DF62BAB CRC64;
     MDAIKKKMQA MKIEKDTALD RADAAKEKVR QMTDKLERIE EELRDTQKKM MQTENDLNKA
     QEDLAVANTN LEDKEKKVQK AEAEVPPLNR RMTLLEEELE RAEERLKIAT DKLEKATHTA
     DESDRVRKVM ENRSFQDEER ANTVESQLKE AQLLAEEADR KYDEVARKLA MVEADLERAE
     ERAEAGENKI VELEEELRVV GNNLKFLEVS EEKALQREDS YEEQIRTVSA RLKEAETRAE
     FAERSVQKLQ KEVDRLEDEL VHEKGRYKNI SEELDQTFQE LFGY