TPM_ANISI
ID TPM_ANISI Reviewed; 284 AA.
AC Q9NAS5;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Tropomyosin;
DE AltName: Allergen=Ani s 3;
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10838230; DOI=10.1016/s0166-6851(00)00218-8;
RA Asturias J.A., Eraso E., Martinez A.;
RT "Cloning and high level expression in Escherichia coli of an Anisakis
RT simplex tropomyosin isoform.";
RL Mol. Biochem. Parasitol. 108:263-267(2000).
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction.
CC -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC polypeptide chains. The sequence exhibits a prominent seven-residues
CC periodicity.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. A.simplex
CC is a fish parasite that, when accidentally ingested by humans, may
CC cause allergic reactions in sensitized individuals.
CC -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR EMBL; Y19221; CAB93501.1; -; mRNA.
DR AlphaFoldDB; Q9NAS5; -.
DR SMR; Q9NAS5; -.
DR Allergome; 3081; Ani s 3.0101.
DR Allergome; 37; Ani s 3.
DR Proteomes; UP000036680; Genome.
DR InterPro; IPR000533; Tropomyosin.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 1: Evidence at protein level;
KW Allergen; Coiled coil; Repeat.
FT CHAIN 1..284
FT /note="Tropomyosin"
FT /id="PRO_0000205643"
FT REGION 110..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..284
FT /evidence="ECO:0000250"
SQ SEQUENCE 284 AA; 33203 MW; 18E979DA698F62FE CRC64;
MDAIKKKMQA MKIEKDNALD RADAAEEKVR QMTDKLERIE EELRDTQKKM MQTENDLDKA
QEDLSTANSN LEEKEKKVQE AEAEVAALNR RMTLLEEELE RAEERLKLAT AKLEEATHTA
DESERVRKVM ENRSFQDEER ANTVESQLKE AQMLAEEADR KYDEVARKLT MVEADLERAE
ERAETGENKI VELEEELRVV GNNLKSLEVS EEKALQREDS YEEQIRTVSA RLKEAETRAE
FAERSVQKLQ KEVDRLEDEL VHEKERYKSI SEELDQTFQE LSGY