ID   TPM_BRABE               Reviewed;         284 AA.
AC   Q9NDS0;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Tropomyosin;
GN   Name=TPM;
OS   Branchiostoma belcheri (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Notochord;
RX   PubMed=10926757; DOI=10.1006/dbio.2000.9796;
RA   Suzuki M.M., Satoh N.;
RT   "Genes expressed in the amphioxus notochord revealed by EST analysis.";
RL   Dev. Biol. 224:168-177(2000).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; AB035663; BAA96548.1; -; mRNA.
DR   AlphaFoldDB; Q9NDS0; -.
DR   SMR; Q9NDS0; -.
DR   Proteomes; UP000515135; Unplaced.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205691"
FT   REGION          106..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        186..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  32565 MW;  5D0E0C923DE97D44 CRC64;
     MDAIKKKMLM LKNDKENALD RAEQAEQAMK DAQEKNVKLE DEINDLNKKI RMVEDELDKA
     QESLKEATEQ LEAATKKAAD AEAEVASLNR RIQLVEEELD RAQERLNSTV EKLTDSEKAA
     DESERARKVL ENRQGADEDK MELLDMQLRE AKMIAEEADR KYEEVARKLV ITEGDLERAE
     ERADLAETKA RELEDELKTT TGQLKSMEAQ ATKASEKEEA YEEQVRDLSA KLKEAETRAE
     FAERTVAKLE KNVDDLEDAL YAEKEKYRGV SEELDQALNE LHNM