TPM_CHIKI
ID TPM_CHIKI Reviewed; 285 AA.
AC O96764;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 2.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Tropomyosin {ECO:0000303|PubMed:15013982};
DE AltName: Full=Allergen Chi k 10 {ECO:0000303|PubMed:15013982};
DE AltName: Allergen=Chi k 10.0101 {ECO:0000305};
OS Chironomus kiiensis (Midge).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Chironominae; Chironomus.
OX NCBI_TaxID=84408;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX PubMed=15013982; DOI=10.1128/cdli.11.2.320-324.2004;
RA Jeong K.Y., Yum H.Y., Lee I.Y., Ree H.I., Hong C.S., Kim D.S., Yong T.S.;
RT "Molecular cloning and characterization of tropomyosin, a major allergen of
RT Chironomus kiiensis, a dominant species of nonbiting midges in Korea.";
RL Clin. Diagn. Lab. Immunol. 11:320-324(2004).
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction. {ECO:0000250|UniProtKB:Q22866}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:A2V735}.
CC -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC polypeptide chains. The sequence exhibits a prominent seven-residues
CC periodicity. {ECO:0000305}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 81% of
CC the 21 patients tested allergic to adult non-biting midge C.kiiensis.
CC {ECO:0000269|PubMed:15013982}.
CC -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR EMBL; AJ012184; CAA09938.2; -; mRNA.
DR AlphaFoldDB; O96764; -.
DR SMR; O96764; -.
DR Allergome; 200; Chi k 10.
DR Allergome; 3191; Chi k 10.0101.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR InterPro; IPR000533; Tropomyosin.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 1: Evidence at protein level;
KW Allergen; Coiled coil; Muscle protein; Repeat.
FT CHAIN 1..285
FT /note="Tropomyosin"
FT /id="PRO_0000205683"
FT COILED 1..273
FT /evidence="ECO:0000255"
SQ SEQUENCE 285 AA; 32533 MW; DCA3FE9C05809FF4 CRC64;
MDAIKKKMQA MKLEKDNALD RALLCENQAR DANLRAEKAE EEARTLQKKI QTIENDLDQT
QGQETLVNGK LEGKEKALQN AESEVAALNR RIQLLGEDLD RSEERLASAT AKLSEASAAA
DESERARKIL ENRSLADEER MDALENQLKE ARFLAEEADK KYDEVARKLA MVEADLERAE
ERAEAGEAKI VELEEELRVV GNNLKSLEVS EEKANQREEE YKNQIKTLTT RLKEAEARAE
FAERSVQKLQ KEVDRLEDEL VSEKEKYREI GDDLDTAFVE LILKE