ID   TPM_CLOSI               Reviewed;         284 AA.
AC   Q23758;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Tropomyosin;
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hong S.-J., Seong Y.-K.;
RT   "Cloning, characterization and expression of Clonorchis sinensis
RT   tropomyosin cDNA.";
RL   Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; L43918; AAA70373.1; -; mRNA.
DR   AlphaFoldDB; Q23758; -.
DR   SMR; Q23758; -.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
PE   2: Evidence at transcript level;
KW   Coiled coil; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205651"
FT   REGION          29..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
FT   COMPBIAS        29..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  32786 MW;  F29E2F7A581137CB CRC64;
     MDGIKKKMIA MKLEKENAME RAVQYEAQLK QKEEEQEKKE TEIGELNNRM KQAQTELDEI
     QEALQDSLNK MEETDKRATN AEAEVARMTR RIRLLEEDLE VSSSRLTETL AKFDEASKTA
     EESERGRKEL EIRSIADDEG LSQLEDQQKE GKYIAEDADR KYDEAARKLA IVEVDFERAE
     SRLEAAESKI VELEEELRVV GNNMKALEIS EQESAQREES YEETIRDLTE RLKAAEQRAA
     EAERQVSKLQ NEVDHLEDDL LSEKIRYKDL SGGLDQTFAE LTGY