ID   TPM_CORAP               Reviewed;         284 AA.
AC   O97192;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Tropomyosin;
DE   AltName: Allergen=Hel as 1;
OS   Cornu aspersum (Brown garden snail) (Helix aspersa).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC   Helicina; Helicoidea; Helicidae; Cornu; Cornu.
OX   NCBI_TaxID=6535;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12065908; DOI=10.1159/000059398;
RA   Asturias J.A., Eraso E., Arilla M.C., Gomez-Bayon N., Inacio F.,
RA   Martinez A.;
RT   "Cloning, isolation, and IgE-binding properties of Helix aspersa (brown
RT   garden snail) tropomyosin.";
RL   Int. Arch. Allergy Immunol. 128:90-96(2002).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; Y14855; CAB38044.1; -; mRNA.
DR   AlphaFoldDB; O97192; -.
DR   SMR; O97192; -.
DR   Allergome; 3309; Hel as 1.0101.
DR   Allergome; 378; Hel as 1.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205667"
FT   REGION          105..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   284 AA;  32637 MW;  01B87021E0F32D4D CRC64;
     MDAIKKKMLA MKMEKENALD RAEQVEQKLR DCECNKNKVE EDLNNLQKKF AILENDFDSI
     NEQLLDANTK LEASEKKNAE IESETAGLQR RIQLLEEDLE RSEERLQSAT EKLEEASKAA
     DESERGRKVL ESRSLADDER LDGLEAQLKE AKYIAEDAER KFDEAARKLA ITEVDLERAE
     ARLEAAEAKI LELEEELKVV GNNMKSLEIS EQEASQREDS YEETIRDLTQ RLKDAENRAS
     EAERTVSKLQ KEVDRLEDEL LAEKERYKAT SDELDSTFAE LAGY