ID   TPM_DERFA               Reviewed;         284 AA.
AC   Q23939;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-FEB-2004, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Tropomyosin;
DE   AltName: Full=Mag44;
DE   AltName: Allergen=Der f 10;
OS   Dermatophagoides farinae (American house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX   NCBI_TaxID=6954;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=7622766; DOI=10.1016/s0091-6749(95)70035-8;
RA   Aki T., Kodama T., Fujikawa A., Miura K., Shigeta S., Wada T., Jyo T.,
RA   Murooka Y., Oka S., Ono K.;
RT   "Immunochemical characterization of recombinant and native tropomyosins as
RT   a new allergen from the house dust mite, Dermatophagoides farinae.";
RL   J. Allergy Clin. Immunol. 96:74-83(1995).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA04557.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D17682; BAA04557.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q23939; -.
DR   SMR; Q23939; -.
DR   Allergome; 296; Der f 10.
DR   Allergome; 3248; Der f 10.0101.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Direct protein sequencing; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205678"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   284 AA;  32955 MW;  E665D29BAAF33507 CRC64;
     MEAIKKKMQA MKLEKDNAID RAEIAEQKAR DANLRAEKSE EEVRALQKKI QQIENELDQV
     QEQLSAANTK LEEKEKALQT AEGDVAALNR RIQLIEEDLE RSEERLKIAT AKLEEASQSA
     DESERMRKML EHRSITDEER MDGLENQLKE ARMMAEDADR KYDEVARKLA MVEADLERAE
     ERAETGESKI VELEEELRVV GNNLKSLEVS EEKAQQREEA YEQQIRIMTA KLKEAEARAE
     FAERSVQKLQ KEVDRLEDEL VHEKEKYKSI SDELDQTFAE LTGY