ID   TPM_DERPT               Reviewed;         284 AA.
AC   O18416; O16188;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Tropomyosin;
DE   AltName: Allergen=Der p 10;
OS   Dermatophagoides pteronyssinus (European house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX   NCBI_TaxID=6956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9545522; DOI=10.1016/s0167-4781(98)00006-2;
RA   Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A.,
RA   Palacios R.;
RT   "Sequencing and high level expression in Escherichia coli of the
RT   tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus.";
RL   Biochim. Biophys. Acta 1397:27-30(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Smith W., Mills K.L., Thomas W.R.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; Y14906; CAA75141.1; -; mRNA.
DR   EMBL; AF016278; AAB69424.1; -; mRNA.
DR   AlphaFoldDB; O18416; -.
DR   SMR; O18416; -.
DR   Allergome; 311; Der p 10.
DR   Allergome; 3258; Der p 10.0101.
DR   Proteomes; UP000515146; Unplaced.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205679"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
FT   CONFLICT        6
FT                   /note="N -> K (in Ref. 2; AAB69424)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        254
FT                   /note="G -> D (in Ref. 2; AAB69424)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   284 AA;  32901 MW;  278AAF663E585DB9 CRC64;
     MEAIKNKMQA MKLEKDNAID RAEIAEQKAR DANLRAEKSE EEVRALQKKI QQIENELDQV
     QEQLSAANTK LEEKEKALQT AEGDVAALNR RIQLIEEDLE RSEERLKIAT AKLEEASQSA
     DESERMRKML EHRSITDEER MEGLENQLKE ARMMAEDADR KYDEVARKLA MVEADLERAE
     ERAETGESKI VELEEELRVV GNNLKSLEVS EEKAQQREEA HEQQIRIMTT KLKEAEARAE
     FAERSVQKLQ KEVGRLEDEL VHEKEKYKSI SDELDQTFAE LTGY