ID   TPM_LEPDS               Reviewed;         284 AA.
AC   Q9NFZ4;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Tropomyosin;
DE   AltName: Allergen=Lep d 10;
OS   Lepidoglyphus destructor (Storage mite) (Glycyphagus destructor).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Glycyphagoidea; Glycyphagidae;
OC   Lepidoglyphus.
OX   NCBI_TaxID=36936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12740526; DOI=10.1159/000070212;
RA   Saarne T., Kaiser L., Rasool O., Huecas S., van Hage-Hamsten M.,
RA   Gafvelin G.;
RT   "Cloning and characterisation of two IgE-binding proteins, homologous to
RT   tropomyosin and alpha-tubulin, from the mite Lepidoglyphus destructor.";
RL   Int. Arch. Allergy Immunol. 130:258-265(2003).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC       allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; AJ250096; CAB71342.1; -; mRNA.
DR   AlphaFoldDB; Q9NFZ4; -.
DR   SMR; Q9NFZ4; -.
DR   Allergome; 3349; Lep d 10.0101.
DR   Allergome; 437; Lep d 10.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205681"
FT   REGION          22..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   284 AA;  32950 MW;  05EED5298696EA08 CRC64;
     MEAIKNKMQA MKLEKDNAID RAEIAEQKSR DANLRAEKSE EEVRGLQKKI QQIENELDQV
     QESLTQANTK LEEKEKSLQT AEGDVAALNR RIQLIEEDLE RSEGRLKIAT SKLEEASQSA
     DESERMRKML EHRSITDEER MEGLESQLKE ARMMAEDADR KYDEVARKLA MVEADLERAE
     ERAETGESKI VELEEELRVV GNNLKSLEVS EEKAQQREEA YEQQIRIMTT KLKEAEARAE
     FAERSVQKLQ KEVDRLEDEL VHEKEKYKSI SDELDQTFAE LTGY