ID   TPM_METEN               Reviewed;         274 AA.
AC   Q25456;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Tropomyosin;
DE   AltName: Full=Allergen Met e I;
DE   AltName: Allergen=Met e 1;
OS   Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Metapenaeus.
OX   NCBI_TaxID=32278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Muscle;
RX   PubMed=7963157; DOI=10.1016/0091-6749(94)90156-2;
RA   Leung P.S.C., Chu K.H., Chow W.K., Ansari A., Bandea C.I., Kwan H.S.,
RA   Nagy S.M., Gershwin M.E.;
RT   "Cloning, expression, and primary structure of Metapenaeus ensis
RT   tropomyosin, the major heat-stable shrimp allergen.";
RL   J. Allergy Clin. Immunol. 94:882-890(1994).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Shrimp is a common
CC       cause of seafood hypersensitivity. This protein is the major heat-
CC       stable shrimp allergen.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; U08008; AAA60330.1; -; mRNA.
DR   AlphaFoldDB; Q25456; -.
DR   SMR; Q25456; -.
DR   Allergome; 3376; Met e 1.0101.
DR   Allergome; 477; Met e 1.
DR   PRIDE; Q25456; -.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Repeat.
FT   CHAIN           1..274
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205675"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..274
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        1..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  31705 MW;  6EE84B5C1E015ECD CRC64;
     MKLEKDNAMD RADTLEQQNK EANNRAEKSE EEVHNLQKRM QQLENDLDQV QESLLKANNQ
     LVEKDKALSN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA DESERMRKVL
     ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKI
     VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE FAERSVQKLQ
     KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY