TPM_MIMNO
ID TPM_MIMNO Reviewed; 284 AA.
AC Q9GZ69;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Tropomyosin {ECO:0000303|PubMed:11246417};
DE AltName: Full=Allergen Chl n 1 {ECO:0000303|PubMed:11246417};
DE AltName: Allergen=Mim n 1 {ECO:0000305};
OS Mimachlamys nobilis (Noble scallop) (Chlamys nobilis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mimachlamys.
OX NCBI_TaxID=106276;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC TISSUE=Adductor muscle {ECO:0000303|PubMed:11246417};
RX PubMed=11246417; DOI=10.1007/s101260000035;
RA Chu K.H., Wong S.H., Leung P.S.;
RT "Tropomyosin Is the Major Mollusk Allergen: Reverse Transcriptase
RT Polymerase Chain Reaction, Expression and IgE Reactivity.";
RL Mar. Biotechnol. 2:499-509(2000).
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction. {ECO:0000250|UniProtKB:Q22866}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:A2V735}.
CC -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC polypeptide chains. The sequence exhibits a prominent seven-residues
CC periodicity. {ECO:0000305}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE of
CC patients allergic to shellfish (mollusks and crustaceans).
CC {ECO:0000269|PubMed:11246417}.
CC -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR EMBL; AF216520; AAG08989.1; -; mRNA.
DR AlphaFoldDB; Q9GZ69; -.
DR SMR; Q9GZ69; -.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR InterPro; IPR000533; Tropomyosin.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 1: Evidence at protein level;
KW Allergen; Coiled coil; Muscle protein; Repeat.
FT CHAIN 1..284
FT /note="Tropomyosin"
FT /id="PRO_0000205668"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..273
FT /evidence="ECO:0000255"
SQ SEQUENCE 284 AA; 32667 MW; AADD83892359522C CRC64;
MDAIKKKMQA MKVDRENAQD LAEQMEQKLK DTETAKAKLE EEFNELQKKL TATENNYDTV
NEQLQEANTK LENSEKQITQ LESDVGGLQR RLTLLEEDYE RSEEKLNSTT EKLEEASKAA
DESERNRKVL EGRSNSYEER IDELEKQLET AKNVATDADH KFDEAARKLA ITEVDLERAE
TRLEAADAKV LELEEELTVV GANIKTLQVQ NDQASQREDS YEETIRDLTK SLKDAENRAT
EAERQVVKLQ KEVDRLEDEL LAEKERYKAI SDDLDQTFAE IAGY