ID   TPM_ONCVO               Reviewed;         284 AA.
AC   Q25632;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Tropomyosin;
DE   AltName: Full=MOv-14;
DE   AltName: Full=Ov-tmy-1;
GN   Name=tmy-1;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=9636187; DOI=10.1073/pnas.95.13.7550;
RA   Jenkins R.E., Taylor M.J., Gilvary N.J., Bianco A.E.;
RT   "Tropomyosin implicated in host protective responses to microfilariae in
RT   onchocerciasis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:7550-7555(1998).
RN   [2]
RP   PARTIAL NUCLEOTIDE SEQUENCE.
RX   PubMed=9229374; DOI=10.1046/j.1365-3024.1996.d01-93.x;
RA   Taylor M.J., Jenkins R.E., Bianco A.E.;
RT   "Protective immunity induced by vaccination with Onchocerca volvulus
RT   tropomyosin in rodents.";
RL   Parasite Immunol. 18:219-225(1996).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- DEVELOPMENTAL STAGE: Present in all life-cycle stages.
CC       {ECO:0000269|PubMed:9636187}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L41633; AAC28900.1; -; mRNA.
DR   AlphaFoldDB; Q25632; -.
DR   SMR; Q25632; -.
DR   STRING; 6282.Q25632; -.
DR   PRIDE; Q25632; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205647"
FT   REGION          112..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..284
SQ   SEQUENCE   284 AA;  33235 MW;  4535A43E593DE7E0 CRC64;
     MDAIKKKMQA MKIEKDNALD RADAAEEKVR QMTEKLERIE EELRDTQKKM MQTENDLVKA
     QEDLSVANTN LEDKEKKVQE AEAEVAALNR RMTLLEEELE RAEERLKIAT DKLEEATHTA
     DESERVRKVM ENRSFQDEER ANTVESQEKE AQLLAEEADR KYDEVARKLA MVEADLERAE
     ERAEAGENEI VELEEELRVV GNNLKSLEVS EEKALQREDS YQEQIRTVSV RLKEAETRAE
     FAERSVQKLQ KKVDRLEDEL VHEKERYKNI SEELDQTFQE LSGY