ID   TPM_PANST               Reviewed;         274 AA.
AC   O61379;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Tropomyosin;
DE   AltName: Full=Allergen Pan s I;
DE   AltName: Allergen=Pan s 1;
OS   Panulirus stimpsoni (Chinese spiny lobster).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Achelata;
OC   Palinuroidea; Palinuridae; Panulirus.
OX   NCBI_TaxID=71578;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RX   PubMed=9597774;
RA   Leung P.S.C., Chen Y.C., Mykles D.L., Chow W.K., Li C.P., Chu K.H.;
RT   "Molecular identification of the lobster muscle protein tropomyosin as a
RT   seafood allergen.";
RL   Mol. Mar. Biol. Biotechnol. 7:12-20(1998).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; AF030063; AAC38996.1; -; mRNA.
DR   AlphaFoldDB; O61379; -.
DR   SMR; O61379; -.
DR   Allergome; 3396; Pan s 1.0101.
DR   Allergome; 500; Pan s 1.
DR   PRIDE; O61379; -.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
DR   PROSITE; PS00326; TROPOMYOSIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Repeat.
FT   CHAIN           1..274
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000205676"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..274
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   274 AA;  31739 MW;  886FACBE8CF1E81E CRC64;
     MKLEKDNAMD RADTLEQQNK EANIRAEKAE EEVHNLQKRM QQLENDLDQV QESLLKANTQ
     LEEKDKALSN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA DESERMRKVL
     ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKF
     VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE FAERSVQKLQ
     KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY