TPM_PENMO
ID TPM_PENMO Reviewed; 284 AA.
AC A1KYZ2;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Tropomyosin {ECO:0000303|Ref.3, ECO:0000312|EMBL:AAX37288.1};
DE AltName: Full=Major allergen Pen m 1 {ECO:0000303|PubMed:23840718};
DE AltName: Full=Tropomyosin, fast isoform {ECO:0000303|PubMed:17263503, ECO:0000312|EMBL:BAF47262.1};
DE Short=Tm-Penm-fast {ECO:0000312|EMBL:BAF47262.1};
DE AltName: Allergen=Pen m 1.0101 {ECO:0000305};
GN Name=TM1 {ECO:0000250|UniProtKB:O44119};
OS Penaeus monodon (Giant tiger prawn).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6687;
RN [1] {ECO:0000312|EMBL:AAX37288.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Chew F.T., Nah H.L.;
RT "Cloning of tropomyosin from Penaeus monodon.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAF47262.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND ALLERGEN.
RC TISSUE=Muscle {ECO:0000269|PubMed:17263503};
RX PubMed=17263503; DOI=10.1021/jf062798x;
RA Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K.;
RT "Molecular cloning of tropomyosins identified as allergens in six species
RT of crustaceans.";
RL J. Agric. Food Chem. 55:985-991(2007).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE, TISSUE SPECIFICITY, ALLERGEN, AND ACETYLATION AT MET-1.
RC TISSUE=Muscle {ECO:0000269|Ref.3};
RX DOI=10.1002/rcm.4664;
RA Abdel Rahman A.M., Kamath S., Lopata A.L., Helleur R.J.;
RT "Analysis of the allergenic proteins in black tiger prawn (Penaeus monodon)
RT and characterization of the major allergen tropomyosin using mass
RT spectrometry.";
RL Rapid Commun. Mass Spectrom. 24:2462-2470(2010).
RN [4]
RP ALLERGEN.
RX PubMed=23840718; DOI=10.1371/journal.pone.0067487;
RA Abramovitch J.B., Kamath S., Varese N., Zubrinich C., Lopata A.L.,
RA O'Hehir R.E., Rolland J.M.;
RT "IgE Reactivity of Blue Swimmer Crab (Portunus pelagicus) Tropomyosin, Por
RT p 1, and Other Allergens; Cross-Reactivity with Black Tiger Prawn and
RT Effects of Heating.";
RL PLoS ONE 8:E67487-E67487(2013).
CC -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC a central role in the calcium dependent regulation of muscle
CC contraction. {ECO:0000250|UniProtKB:Q22866}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:A2V735}.
CC -!- TISSUE SPECIFICITY: Expressed in muscle (at protein level).
CC {ECO:0000269|PubMed:17263503, ECO:0000269|Ref.3}.
CC -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC polypeptide chains. The sequence exhibits a prominent seven-residues
CC periodicity. {ECO:0000305}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE of
CC patients allergic to crustaceans (PubMed:17263503, Ref.3,
CC PubMed:23840718). Heating increases IgE-binding activity. Cross-reacts
CC with blue swimmer crab tropomyosin allergen Por p 1.0101. Recombinant
CC protein causes activation of basophils (PubMed:23840718).
CC {ECO:0000269|PubMed:17263503, ECO:0000269|PubMed:23840718,
CC ECO:0000269|Ref.3}.
CC -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000255}.
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DR EMBL; AY827100; AAX37288.1; -; mRNA.
DR EMBL; AB270629; BAF47262.1; -; mRNA.
DR AlphaFoldDB; A1KYZ2; -.
DR SMR; A1KYZ2; -.
DR Allergome; 3410; Pen m 1.0101.
DR Allergome; 972; Pen m 1.
DR InterPro; IPR000533; Tropomyosin.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Allergen; Coiled coil; Direct protein sequencing;
KW Muscle protein; Repeat.
FT CHAIN 1..284
FT /note="Tropomyosin"
FT /id="PRO_0000398788"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..284
FT /evidence="ECO:0000250|UniProtKB:O44119"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|Ref.3"
SQ SEQUENCE 284 AA; 32849 MW; BE53B602C37E85E2 CRC64;
MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANNRAEKSE EEVHNLQKRM QQLENDLDQV
QESLLKANIQ LVEKDKALSN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA
DESERMRKVL ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE
ERAETGESKI VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE
FAERSVQKLQ KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY