ID   TPM_SINCO               Reviewed;         284 AA.
AC   A7UMC0;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Tropomyosin {ECO:0000303|PubMed:18046627};
DE   AltName: Full=Allergen Sin c 1 {ECO:0000305};
DE   AltName: Allergen=Sin c 1.0102 {ECO:0000305};
OS   Sinonovacula constricta (Razor clam).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC   Cardiida; Tellinoidea; Solecurtidae; Sinonovacula.
OX   NCBI_TaxID=98310 {ECO:0000312|EMBL:ABU53681.1};
RN   [1] {ECO:0000312|EMBL:ABU53681.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=18046627; DOI=10.1007/s11033-007-9181-4;
RA   Song J., Li L., Liu Z., Li Q., Ran P.;
RT   "Sequence analysis and expression of a cDNA clone encoding tropomysin in
RT   Sinonovacula constricta.";
RL   Mol. Biol. Rep. 36:315-321(2009).
CC   -!- FUNCTION: Tropomyosin, in association with the troponin complex, plays
CC       a central role in the calcium dependent regulation of muscle
CC       contraction. {ECO:0000250|UniProtKB:Q22866}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:A2V735}.
CC   -!- DOMAIN: The molecule is in a coiled coil structure that is formed by 2
CC       polypeptide chains. The sequence exhibits a prominent seven-residues
CC       periodicity. {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 36% of
CC       the 11 patients tested allergic to mollusk S.constricta.
CC       {ECO:0000269|PubMed:18046627}.
CC   -!- SIMILARITY: Belongs to the tropomyosin family. {ECO:0000305}.
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DR   EMBL; EU082209; ABU53681.1; -; mRNA.
DR   AlphaFoldDB; A7UMC0; -.
DR   SMR; A7UMC0; -.
DR   Allergome; 3992; Sin c 1.
DR   PRIDE; A7UMC0; -.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006937; P:regulation of muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR000533; Tropomyosin.
DR   Pfam; PF00261; Tropomyosin; 1.
DR   PRINTS; PR00194; TROPOMYOSIN.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Muscle protein; Repeat.
FT   CHAIN           1..284
FT                   /note="Tropomyosin"
FT                   /id="PRO_0000447295"
FT   COILED          1..280
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  32957 MW;  654B14E7D1311CD6 CRC64;
     MDAIKKKMQA MKIEKENALD KSEQLENKLK EIEDVKVKIE EDLTSLQKKY TNQENEYDKV
     NEQFNESTVK LEASEKRVTE CEDEIKGFTR RIQLLEDELE RTQQKAEEAV LKLEEASKAA
     DESERGRKVL ESRSIADDDR IDKLEKDVKD SKYLAEEADR KYDEAARKLA ITEVDLERAE
     TRLEAAESKI TELSEELQVV GNNCKALQNA VDQASQREDS YEETIRDLTQ RLKDAENRAA
     EAERVVNKLQ KEVDRLEDEL LQEKEKYKQI SDELDQTFAE LAGM