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TPN32_TREPA
ID   TPN32_TREPA             Reviewed;         268 AA.
AC   O07950;
DT   04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Membrane lipoprotein TpN32;
DE   AltName: Full=29 kDa protein;
DE   Flags: Precursor;
GN   Name=tpn32; OrderedLocusNames=TP_0821;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Porcella S.F., Radolf J.D., Norgard M.V.;
RT   "Treponema pallidum 29K protein is homologous to a lipoprotein present in
RT   Pasteurella hemolytica and in Haemophilus influenzae type b.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RA   Stamm L.V., Barnes N.Y.;
RT   "Treponema pallidum lipoprotein homologue.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NlpA lipoprotein family. {ECO:0000305}.
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DR   EMBL; U97358; AAB63362.1; -; Genomic_DNA.
DR   EMBL; U93844; AAB61267.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65789.1; -; Genomic_DNA.
DR   PIR; G71275; G71275.
DR   RefSeq; WP_010882265.1; NC_021490.2.
DR   PDB; 1XS5; X-ray; 1.85 A; A=28-268.
DR   PDBsum; 1XS5; -.
DR   AlphaFoldDB; O07950; -.
DR   SMR; O07950; -.
DR   STRING; 243276.TPANIC_0821; -.
DR   EnsemblBacteria; AAC65789; AAC65789; TP_0821.
DR   GeneID; 57879338; -.
DR   KEGG; tpa:TP_0821; -.
DR   eggNOG; COG1464; Bacteria.
DR   HOGENOM; CLU_067080_0_0_12; -.
DR   OMA; YQDDAES; -.
DR   OrthoDB; 1230456at2; -.
DR   EvolutionaryTrace; O07950; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004872; Lipoprotein_NlpA.
DR   PANTHER; PTHR30429; PTHR30429; 1.
DR   Pfam; PF03180; Lipoprotein_9; 1.
DR   PIRSF; PIRSF002854; MetQ; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           24..268
FT                   /note="Membrane lipoprotein TpN32"
FT                   /id="PRO_0000019750"
FT   LIPID           24
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           24
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   STRAND          30..36
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           41..53
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   TURN            54..56
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          57..63
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           67..75
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          78..86
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           87..97
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          101..109
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          113..115
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           122..124
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          130..134
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           137..149
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           165..167
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          168..170
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          176..180
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           182..184
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           185..188
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           189..191
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          192..197
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           199..204
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   TURN            209..212
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          214..216
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           220..223
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          225..230
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           237..246
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   HELIX           249..258
FT                   /evidence="ECO:0007829|PDB:1XS5"
FT   STRAND          262..266
FT                   /evidence="ECO:0007829|PDB:1XS5"
SQ   SEQUENCE   268 AA;  29081 MW;  AB21F8A07A88F691 CRC64;
     MKGKTVSAAL VGKLIALSVG VVACTQVKDE TVGVGVLSEP HARLLEIAKE EVKKQHIELR
     IVEFTNYVAL NEAVMRGDIL MNFFQHVPHM QQFNQEHNGD LVSVGNVHVE PLALYSRTYR
     HVSDFPAGAV IAIPNDSSNE ARALRLLEAA GFIRMRAGSG LFATVEDVQQ NVRNVVLQEV
     ESALLPRVFD QVDGAVINGN YAIMAGLSAR RDGLAVEPDA SAYANVLVVK RGNEADARVQ
     AVLRALCGGR VRTYLKERYK GGEVAPAL
 
 
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