ID   TPN50_TREPA             Reviewed;         417 AA.
AC   P38369; Q56358;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Outer membrane protein Tpn50;
DE   AltName: Full=Antigen Tpp57;
DE   Flags: Precursor;
GN   Name=tpn50; OrderedLocusNames=TP_0292;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=8112835; DOI=10.1128/iai.62.3.1015-1025.1994;
RA   Hardham J.M., Stamm L.V.;
RT   "Identification and characterization of the Treponema pallidum tpn50 gene,
RT   an ompA homolog.";
RL   Infect. Immun. 62:1015-1025(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=7623668; DOI=10.1111/j.1365-2958.1995.tb02288.x;
RA   Cox D.L., Akins D.R., Porcella S.F., Norgard M.V., Radolf J.D.;
RT   "Treponema pallidum in gel microdroplets: a novel strategy for
RT   investigation of treponemal molecular architecture.";
RL   Mol. Microbiol. 15:1151-1164(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Could function as a porin.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       {ECO:0000305}.
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DR   EMBL; U02628; AAA20517.2; -; Genomic_DNA.
DR   EMBL; L28427; AAA99311.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65272.1; -; Genomic_DNA.
DR   PIR; G71344; G71344.
DR   RefSeq; WP_010881741.1; NC_021490.2.
DR   AlphaFoldDB; P38369; -.
DR   SMR; P38369; -.
DR   IntAct; P38369; 1.
DR   STRING; 243276.TPANIC_0292; -.
DR   EnsemblBacteria; AAC65272; AAC65272; TP_0292.
DR   GeneID; 57878830; -.
DR   KEGG; tpa:TP_0292; -.
DR   eggNOG; COG2885; Bacteria.
DR   HOGENOM; CLU_045523_1_0_12; -.
DR   OMA; RGIPRFP; -.
DR   OrthoDB; 583204at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd07185; OmpA_C-like; 1.
DR   Gene3D; 3.30.1330.60; -; 1.
DR   InterPro; IPR006664; OMP_bac.
DR   InterPro; IPR006665; OmpA-like.
DR   InterPro; IPR006690; OMPA-like_CS.
DR   InterPro; IPR036737; OmpA-like_sf.
DR   Pfam; PF00691; OmpA; 1.
DR   PRINTS; PR01021; OMPADOMAIN.
DR   SUPFAM; SSF103088; SSF103088; 1.
DR   PROSITE; PS01068; OMPA_1; 1.
DR   PROSITE; PS51123; OMPA_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..417
FT                   /note="Outer membrane protein Tpn50"
FT                   /id="PRO_0000020118"
FT   DOMAIN          300..417
FT                   /note="OmpA-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT   CONFLICT        127
FT                   /note="Missing (in Ref. 2; AAA99311)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        350
FT                   /note="A -> E (in Ref. 2; AAA99311)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   417 AA;  47609 MW;  079F579CFDD7288C CRC64;
     MCMMGSVFSR KGMLCVLAVW CAASAAYPLR LRYKFRKGDT HRINSLIRED VFVNDTLAHT
     AEITNRITVH VSEVRVAHGS APDAARYVCH FMTSEKSPNN TFRWGRHYES IFWRDAFGVY
     DIDRSFFMPV VRNVPVFPDY DIEVGDTWEH EAEEAHDLRD GFGIQTPFIV PFTVSYTYRG
     EVQRGSRRYH HITAAYSMSY ESPKRTHGVQ RNAKEGMYPV RTTGVSKQNL YWDNELGNIA
     EYDDEFRILL YLSGGTVLRY QGTATAKNFA PERFDPARTV VELQETLKDL HMPDAKVRET
     EEGVTISIEN VQFDADSASL APSEYEKLRK IAELLRAFPD RELLVSGHAA RRGSVQDQQR
     ISEERADVVA RYLQELGVVD AAHVYTRGCG AQQSIAPNDS EDGRRKNRRV EITIISK