ID   TPO_PIG                 Reviewed;          26 AA.
AC   P42706;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Thrombopoietin;
DE   AltName: Full=C-MPL ligand;
DE            Short=ML;
DE   AltName: Full=Megakaryocyte colony-stimulating factor;
DE   AltName: Full=Megakaryocyte growth and development factor;
DE            Short=MGDF;
DE   Flags: Fragment;
GN   Name=THPO;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Plasma;
RX   PubMed=8202154; DOI=10.1038/369533a0;
RA   de Sauvage F.J., Hass P.E., Spencer S.D., Malloy B.E., Gurney A.L.,
RA   Spencer S.A., Darbonne W.C., Henzel W.J., Wong S.C., Kuang W.-J.,
RA   Oles K.J., Hultgren B., Solberg L.A. Jr., Goeddel D.V., Eaton D.L.;
RT   "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl
RT   ligand.";
RL   Nature 369:533-538(1994).
CC   -!- FUNCTION: Lineage-specific cytokine affecting the proliferation and
CC       maturation of megakaryocytes from their committed progenitor cells. It
CC       acts at a late stage of megakaryocyte development. It may be the major
CC       physiological regulator of circulating platelets.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: Two-domain structure with an erythropoietin-like N-terminal and
CC       a Ser/Pro/Thr-rich C-terminal.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
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DR   AlphaFoldDB; P42706; -.
DR   SMR; P42706; -.
DR   STRING; 9823.ENSSSCP00000023667; -.
DR   PaxDb; P42706; -.
DR   eggNOG; ENOG502S9T0; Eukaryota.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0038163; P:thrombopoietin-mediated signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   CHAIN           1..>26
FT                   /note="Thrombopoietin"
FT                   /id="PRO_0000147103"
FT   NON_TER         26
SQ   SEQUENCE   26 AA;  2904 MW;  F4D353F5C53519D4 CRC64;
     SPAPPACDPR LLNKLLRDDH VLHGRL