ID   TPP4_ORYSJ              Reviewed;         367 AA.
AC   Q6ZGP8; A0A0P0VPT5;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Probable trehalose-phosphate phosphatase 4;
DE            Short=OsTPP4;
DE            EC=3.1.3.12;
DE   AltName: Full=Trehalose 6-phosphate phosphatase;
GN   Name=TPP4; OrderedLocusNames=Os02g0753000, LOC_Os02g51680;
GN   ORFNames=OJ1288_G09.15, OsJ_08413;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Yukihikari;
RX   PubMed=16240171; DOI=10.1007/s11103-005-7404-4;
RA   Pramanik M.H., Imai R.;
RT   "Functional identification of a trehalose 6-phosphate phosphatase gene that
RT   is involved in transient induction of trehalose biosynthesis during
RT   chilling stress in rice.";
RL   Plant Mol. Biol. 58:751-762(2005).
CC   -!- FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce
CC       free trehalose. Trehalose accumulation in plant may improve abiotic
CC       stress tolerance (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-
CC         trehalose + phosphate; Xref=Rhea:RHEA:23420, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:43474, ChEBI:CHEBI:58429; EC=3.1.3.12;
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC   -!- SIMILARITY: Belongs to the trehalose phosphatase family. {ECO:0000305}.
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DR   EMBL; AP004119; BAD15563.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF10057.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS80964.1; -; Genomic_DNA.
DR   EMBL; CM000139; EEE57820.1; -; Genomic_DNA.
DR   EMBL; AK121015; BAH00277.1; -; mRNA.
DR   RefSeq; XP_015623803.1; XM_015768317.1.
DR   AlphaFoldDB; Q6ZGP8; -.
DR   SMR; Q6ZGP8; -.
DR   STRING; 4530.OS02T0753000-01; -.
DR   PaxDb; Q6ZGP8; -.
DR   PRIDE; Q6ZGP8; -.
DR   EnsemblPlants; Os02t0753000-01; Os02t0753000-01; Os02g0753000.
DR   GeneID; 4330753; -.
DR   Gramene; Os02t0753000-01; Os02t0753000-01; Os02g0753000.
DR   KEGG; osa:4330753; -.
DR   eggNOG; KOG1050; Eukaryota.
DR   HOGENOM; CLU_037265_1_2_1; -.
DR   InParanoid; Q6ZGP8; -.
DR   OMA; HKLAKHP; -.
DR   OrthoDB; 974358at2759; -.
DR   UniPathway; UPA00299; -.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000007752; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   Genevisible; Q6ZGP8; OS.
DR   GO; GO:0004805; F:trehalose-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006379; HAD-SF_hydro_IIB.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR044651; OTSB-like.
DR   InterPro; IPR003337; Trehalose_PPase.
DR   PANTHER; PTHR43768; PTHR43768; 1.
DR   Pfam; PF02358; Trehalose_PPase; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR   TIGRFAMs; TIGR00685; T6PP; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Reference proteome; Stress response.
FT   CHAIN           1..367
FT                   /note="Probable trehalose-phosphate phosphatase 4"
FT                   /id="PRO_0000417656"
SQ   SEQUENCE   367 AA;  40018 MW;  16B6EC1FFE085E54 CRC64;
     MTNQDVVVSE MGIAAGAALP GGPAGPAGGL FACRSAAASM RQTYLDLAAA AVAARSASCT
     SWADAMRASS PTRSSRSASD VDEFTAWVRK HPSALSKFEE IAAKSRGKKI VMFMDYDGTL
     SPIVADPDTA YMSDAMRAAV REVAKTFPTA IVSGRCRDKV RNFVGLSDLY YAGSHGMDIK
     GPSSNPESAL CQPASEFLPM IDEVYKTLVE KTKSTPGAKV ENNKFCLSVH FRCVDEKRWN
     ALGEQVKAVI KEYPKLKLTQ GRKVLEIRPS IEWDKGKALE FLLESLGFAN CGDVMPVYIG
     DDRTDEDAFK VLRKRGQGLG ILVSKCPKDT NASYSLQDPT EVMEFLLRLV EWKRKSSSSS
     LMIRPRV