TPPC1_HUMAN
ID TPPC1_HUMAN Reviewed; 145 AA.
AC Q9Y5R8; D3DTR0;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Trafficking protein particle complex subunit 1;
DE AltName: Full=BET5 homolog;
DE AltName: Full=Multiple myeloma protein 2;
DE Short=MUM-2;
GN Name=TRAPPC1 {ECO:0000312|HGNC:HGNC:19894};
GN Synonyms=BET5, MUM2 {ECO:0000303|PubMed:16828797};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MELANOMA GLY-129.
RX PubMed=10582700;
RA Chiari R., Foury F., De Plaen E., Baurain J.-F., Thonnard J., Coulie P.G.;
RT "Two antigens recognized by autologous cytolytic T lymphocytes on a
RT melanoma result from a single point mutation in an essential housekeeping
RT gene.";
RL Cancer Res. 59:5785-5792(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION IN TRAPP COMPLEX.
RX PubMed=11805826; DOI=10.1038/415141a;
RA Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A.,
RA Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C.,
RA Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M.,
RA Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C.,
RA Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V.,
RA Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B.,
RA Neubauer G., Superti-Furga G.;
RT "Functional organization of the yeast proteome by systematic analysis of
RT protein complexes.";
RL Nature 415:141-147(2002).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP SUBUNIT, AND INTERACTION WITH TRAPPC6B AND TRAPPC3.
RX PubMed=16828797; DOI=10.1016/j.jmb.2006.06.012;
RA Kummel D., Muller J.J., Roske Y., Henke N., Heinemann U.;
RT "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric
RT complexes with Bet3 and Mum2.";
RL J. Mol. Biol. 361:22-32(2006).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi.
CC -!- SUBUNIT: Part of the multisubunit transport protein particle (TRAPP)
CC complex (PubMed:11805826). The heterodimer TRAPPC6B-TRAPPC3 interacts
CC with TRAPPC1 likely providing a core for TRAPP complex formation
CC (PubMed:16828797). {ECO:0000269|PubMed:11805826,
CC ECO:0000269|PubMed:16828797}.
CC -!- INTERACTION:
CC Q9Y5R8; O43617: TRAPPC3; NbExp=6; IntAct=EBI-6160554, EBI-743566;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET5 subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF129332; AAD44697.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90109.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90110.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90111.1; -; Genomic_DNA.
DR EMBL; BC032717; AAH32717.1; -; mRNA.
DR CCDS; CCDS11125.1; -.
DR RefSeq; NP_001160093.1; NM_001166621.1.
DR RefSeq; NP_067033.1; NM_021210.4.
DR AlphaFoldDB; Q9Y5R8; -.
DR SMR; Q9Y5R8; -.
DR BioGRID; 121815; 53.
DR ComplexPortal; CPX-4749; TRAPP II complex, TRAPPC2 variant.
DR ComplexPortal; CPX-4750; TRAPP III complex, TRAPPC2 variant.
DR ComplexPortal; CPX-6902; TRAPP II complex, TRAPPC2B variant.
DR ComplexPortal; CPX-6903; TRAPP III complex, TRAPPC2B variant.
DR CORUM; Q9Y5R8; -.
DR DIP; DIP-48285N; -.
DR IntAct; Q9Y5R8; 27.
DR STRING; 9606.ENSP00000302783; -.
DR DrugBank; DB08342; S-palmitoyl-L-cysteine.
DR iPTMnet; Q9Y5R8; -.
DR PhosphoSitePlus; Q9Y5R8; -.
DR BioMuta; TRAPPC1; -.
DR EPD; Q9Y5R8; -.
DR jPOST; Q9Y5R8; -.
DR MassIVE; Q9Y5R8; -.
DR MaxQB; Q9Y5R8; -.
DR PaxDb; Q9Y5R8; -.
DR PeptideAtlas; Q9Y5R8; -.
DR PRIDE; Q9Y5R8; -.
DR ProteomicsDB; 86488; -.
DR Antibodypedia; 24467; 72 antibodies from 22 providers.
DR DNASU; 58485; -.
DR Ensembl; ENST00000303731.9; ENSP00000302783.4; ENSG00000170043.12.
DR Ensembl; ENST00000540486.5; ENSP00000441130.1; ENSG00000170043.12.
DR GeneID; 58485; -.
DR KEGG; hsa:58485; -.
DR MANE-Select; ENST00000303731.9; ENSP00000302783.4; NM_021210.5; NP_067033.1.
DR UCSC; uc002gjo.3; human.
DR CTD; 58485; -.
DR DisGeNET; 58485; -.
DR GeneCards; TRAPPC1; -.
DR HGNC; HGNC:19894; TRAPPC1.
DR HPA; ENSG00000170043; Low tissue specificity.
DR MIM; 610969; gene.
DR neXtProt; NX_Q9Y5R8; -.
DR OpenTargets; ENSG00000170043; -.
DR PharmGKB; PA134988492; -.
DR VEuPathDB; HostDB:ENSG00000170043; -.
DR eggNOG; KOG3368; Eukaryota.
DR GeneTree; ENSGT00940000153761; -.
DR HOGENOM; CLU_053380_4_1_1; -.
DR InParanoid; Q9Y5R8; -.
DR OMA; HYFETPT; -.
DR OrthoDB; 1431711at2759; -.
DR PhylomeDB; Q9Y5R8; -.
DR TreeFam; TF323681; -.
DR PathwayCommons; Q9Y5R8; -.
DR Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR SignaLink; Q9Y5R8; -.
DR BioGRID-ORCS; 58485; 748 hits in 1097 CRISPR screens.
DR ChiTaRS; TRAPPC1; human.
DR GenomeRNAi; 58485; -.
DR Pharos; Q9Y5R8; Tbio.
DR PRO; PR:Q9Y5R8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9Y5R8; protein.
DR Bgee; ENSG00000170043; Expressed in monocyte and 172 other tissues.
DR ExpressionAtlas; Q9Y5R8; baseline and differential.
DR Genevisible; Q9Y5R8; HS.
DR GO; GO:0035578; C:azurophil granule lumen; TAS:Reactome.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR GO; GO:1990071; C:TRAPPII protein complex; IC:ComplexPortal.
DR GO; GO:1990072; C:TRAPPIII protein complex; IC:ComplexPortal.
DR GO; GO:0048208; P:COPII vesicle coating; IC:ComplexPortal.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR007233; TRAPPC.
DR PANTHER; PTHR23249; PTHR23249; 1.
DR Pfam; PF04099; Sybindin; 1.
DR SMART; SM01399; Sybindin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Reference proteome; Transport.
FT CHAIN 1..145
FT /note="Trafficking protein particle complex subunit 1"
FT /id="PRO_0000211562"
FT VARIANT 129
FT /note="R -> G (in a melanoma; dbSNP:rs200476704)"
FT /evidence="ECO:0000269|PubMed:10582700"
FT /id="VAR_013028"
SQ SEQUENCE 145 AA; 16832 MW; 7C8C81D3F0E8DCC6 CRC64;
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG
FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVELVV KNPLCPLGQT
VQSELFRSRL DSYVRSLPFF SARAG
