TPPC1_MOUSE
ID TPPC1_MOUSE Reviewed; 145 AA.
AC Q5NCF2;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Trafficking protein particle complex subunit 1;
GN Name=Trappc1 {ECO:0000312|MGI:MGI:1098727};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi. {ECO:0000250}.
CC -!- SUBUNIT: Part of the multisubunit transport protein particle (TRAPP)
CC complex. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely
CC providing a core for TRAPP complex formation.
CC {ECO:0000250|UniProtKB:Q9Y5R8}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET5 subfamily.
CC {ECO:0000305}.
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DR EMBL; AL645527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24889.1; -.
DR RefSeq; NP_001019377.1; NM_001024206.2.
DR PDB; 2J3T; X-ray; 2.40 A; C=1-145.
DR PDBsum; 2J3T; -.
DR AlphaFoldDB; Q5NCF2; -.
DR SMR; Q5NCF2; -.
DR BioGRID; 232834; 7.
DR ComplexPortal; CPX-4764; TRAPP II complex.
DR ComplexPortal; CPX-4766; TRAPP III complex.
DR IntAct; Q5NCF2; 1.
DR STRING; 10090.ENSMUSP00000099662; -.
DR iPTMnet; Q5NCF2; -.
DR PhosphoSitePlus; Q5NCF2; -.
DR EPD; Q5NCF2; -.
DR MaxQB; Q5NCF2; -.
DR PaxDb; Q5NCF2; -.
DR PRIDE; Q5NCF2; -.
DR ProteomicsDB; 260730; -.
DR Antibodypedia; 24467; 72 antibodies from 22 providers.
DR Ensembl; ENSMUST00000102601; ENSMUSP00000099661; ENSMUSG00000049299.
DR Ensembl; ENSMUST00000102602; ENSMUSP00000099662; ENSMUSG00000049299.
DR GeneID; 245828; -.
DR KEGG; mmu:245828; -.
DR UCSC; uc007jpq.2; mouse.
DR CTD; 58485; -.
DR MGI; MGI:1098727; Trappc1.
DR VEuPathDB; HostDB:ENSMUSG00000049299; -.
DR eggNOG; KOG3368; Eukaryota.
DR GeneTree; ENSGT00940000153761; -.
DR HOGENOM; CLU_053380_4_1_1; -.
DR InParanoid; Q5NCF2; -.
DR OMA; HYFETPT; -.
DR OrthoDB; 1431711at2759; -.
DR TreeFam; TF323681; -.
DR Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR BioGRID-ORCS; 245828; 25 hits in 74 CRISPR screens.
DR ChiTaRS; Trappc1; mouse.
DR EvolutionaryTrace; Q5NCF2; -.
DR PRO; PR:Q5NCF2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5NCF2; protein.
DR Bgee; ENSMUSG00000049299; Expressed in saccule of membranous labyrinth and 267 other tissues.
DR ExpressionAtlas; Q5NCF2; baseline and differential.
DR Genevisible; Q5NCF2; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030008; C:TRAPP complex; IDA:MGI.
DR GO; GO:1990071; C:TRAPPII protein complex; IC:ComplexPortal.
DR GO; GO:1990072; C:TRAPPIII protein complex; IC:ComplexPortal.
DR GO; GO:0048208; P:COPII vesicle coating; IC:ComplexPortal.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR007233; TRAPPC.
DR PANTHER; PTHR23249; PTHR23249; 1.
DR Pfam; PF04099; Sybindin; 1.
DR SMART; SM01399; Sybindin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Reference proteome; Transport.
FT CHAIN 1..145
FT /note="Trafficking protein particle complex subunit 1"
FT /id="PRO_0000211563"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:2J3T"
FT STRAND 15..22
FT /evidence="ECO:0007829|PDB:2J3T"
FT HELIX 31..52
FT /evidence="ECO:0007829|PDB:2J3T"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:2J3T"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:2J3T"
FT STRAND 81..86
FT /evidence="ECO:0007829|PDB:2J3T"
FT HELIX 94..102
FT /evidence="ECO:0007829|PDB:2J3T"
FT HELIX 105..108
FT /evidence="ECO:0007829|PDB:2J3T"
FT TURN 109..111
FT /evidence="ECO:0007829|PDB:2J3T"
FT HELIX 124..134
FT /evidence="ECO:0007829|PDB:2J3T"
SQ SEQUENCE 145 AA; 16882 MW; 7C8C9FCC1118CDC7 CRC64;
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG
FLSFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVEFVV KNPLCPLGQT
VQSELFRSRL DSYVRSLPFF SARAG
