ID   TPPC2_BOVIN             Reviewed;         140 AA.
AC   Q3T0F2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Trafficking protein particle complex subunit 2;
GN   Name=TRAPPC2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prevents ENO1-mediated transcriptional repression and
CC       antagonizes ENO1-mediated cell death. May play a role in vesicular
CC       transport from endoplasmic reticulum to Golgi (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC       complex. Interacts with ENO1, PITX1, SF1, TRAPPC2L and TRAPPC3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:P0DI81}. Nucleus {ECO:0000250|UniProtKB:P0DI81}.
CC       Endoplasmic reticulum-Golgi intermediate compartment
CC       {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P0DI81}. Note=Localized in perinuclear granular
CC       structures. {ECO:0000250|UniProtKB:P0DI81}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. Sedlin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC102418; AAI02419.1; -; mRNA.
DR   RefSeq; NP_001029968.1; NM_001034796.1.
DR   AlphaFoldDB; Q3T0F2; -.
DR   SMR; Q3T0F2; -.
DR   IntAct; Q3T0F2; 2.
DR   STRING; 9913.ENSBTAP00000014509; -.
DR   PaxDb; Q3T0F2; -.
DR   PRIDE; Q3T0F2; -.
DR   Ensembl; ENSBTAT00000014509; ENSBTAP00000014509; ENSBTAG00000010922.
DR   GeneID; 616748; -.
DR   KEGG; bta:616748; -.
DR   CTD; 6399; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010922; -.
DR   eggNOG; KOG3487; Eukaryota.
DR   GeneTree; ENSGT00510000047168; -.
DR   HOGENOM; CLU_085828_0_2_1; -.
DR   InParanoid; Q3T0F2; -.
DR   OMA; VDKFNQW; -.
DR   OrthoDB; 1426075at2759; -.
DR   TreeFam; TF314814; -.
DR   Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-BTA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000010922; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR006722; Sedlin.
DR   PANTHER; PTHR12403; PTHR12403; 1.
DR   Pfam; PF04628; Sedlin_N; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; ER-Golgi transport; Nucleus; Reference proteome; Transcription;
KW   Transport.
FT   CHAIN           1..140
FT                   /note="Trafficking protein particle complex subunit 2"
FT                   /id="PRO_0000260208"
SQ   SEQUENCE   140 AA;  16415 MW;  9EF9942B64E527DD CRC64;
     MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY
     LKTVDKFNEW FVSAFVTAGH MRFIMLHDVR QEDGIKNFFT DVYDLYIKFA MNPFYEPNSP
     IRSSAFDRKV QFLGKKHLLS