TPPC2_CAEEL
ID TPPC2_CAEEL Reviewed; 141 AA.
AC O02173;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Probable trafficking protein particle complex subunit 2;
GN Name=sedl-1; ORFNames=W05H7.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=16862146; DOI=10.1038/ncbl439;
RA Saleh M.-C., van Rij R.P., Hekele A., Gillis A., Foley E., O'Farrell P.H.,
RA Andino R.;
RT "The endocytic pathway mediates cell entry of dsRNA to induce RNAi
RT silencing.";
RL Nat. Cell Biol. 8:793-802(2006).
CC -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC reticulum to Golgi. Required for the systemic spread of the RNAi
CC response. {ECO:0000269|PubMed:16862146}.
CC -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC complex. {ECO:0000250}.
CC -!- INTERACTION:
CC O02173; Q9NA81: trpp-5; NbExp=3; IntAct=EBI-367809, EBI-367817;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAPP small subunits family. Sedlin
CC subfamily. {ECO:0000305}.
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DR EMBL; FO080991; CCD68293.1; -; Genomic_DNA.
DR PIR; T29507; T29507.
DR RefSeq; NP_508272.1; NM_075871.5.
DR AlphaFoldDB; O02173; -.
DR SMR; O02173; -.
DR BioGRID; 45430; 1.
DR IntAct; O02173; 2.
DR STRING; 6239.W05H7.3; -.
DR EPD; O02173; -.
DR PaxDb; O02173; -.
DR PeptideAtlas; O02173; -.
DR EnsemblMetazoa; W05H7.3.1; W05H7.3.1; WBGene00021046.
DR GeneID; 180478; -.
DR KEGG; cel:CELE_W05H7.3; -.
DR UCSC; W05H7.3; c. elegans.
DR CTD; 180478; -.
DR WormBase; W05H7.3; CE14652; WBGene00021046; sedl-1.
DR eggNOG; KOG3487; Eukaryota.
DR GeneTree; ENSGT00940000164277; -.
DR HOGENOM; CLU_085828_0_2_1; -.
DR InParanoid; O02173; -.
DR OMA; VDKFNQW; -.
DR OrthoDB; 1426075at2759; -.
DR PhylomeDB; O02173; -.
DR Reactome; R-CEL-204005; COPII-mediated vesicle transport.
DR Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:O02173; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00021046; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR006722; Sedlin.
DR PANTHER; PTHR12403; PTHR12403; 1.
DR Pfam; PF04628; Sedlin_N; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Reference proteome; Transport.
FT CHAIN 1..141
FT /note="Probable trafficking protein particle complex
FT subunit 2"
FT /id="PRO_0000412461"
SQ SEQUENCE 141 AA; 16632 MW; 5DE15097C1B0C90F CRC64;
MATKEFYFAI IGHCDQPIFE MDFPVGEKKT KESEGTRHLN HYIGHAALDI VDEHALTTSQ
MYLKMVDKFN EWYVSAFVTA SRIRFIMLHT HRADEGIKQF FQEMYETYIK HAMNPFYEID
DVIESPAFEQ KATLYGRKYL S
